心力衰竭患者三种心肌细胞应激标志物的临床分析.pdfVIP

广州医学院硕士论文 心力衰竭患者三种心肌细胞应激标志物的临床研究 multi-marker strategy will help improve patient risk stratification of reasons for the death of, improve diagnosis, effective monitoring, the clinical value of targeted therapy. Myocardial stress markers series in patients with heart failure seems to be more comprehensive in the above series of purpose. However, adrenomedullin and ST2 appear to yield information independently, and thus supplementary to more messages, that provided by the natriuretic peptides. So this becomes our research topic. Objective This study was designed to monitor NT-pro-BNP、BNP 、ST2 blood concentration levels of patients with heart failure and the control group of non-heart failure patients. To explore the blood concentration levels of myocardial stress markers and clinical significance in patients with heart failure. Further analysis multiple factors of stress markers in patients with heart failure and relationship between heart function, LVEF and stress markers serum levels. By constructing ROC curves to selected a largest diagnosis significance marker to judge heart failure. METHODS Case inclusion criteria for control: choice from patients in Guang Zhou City No. 1 Peoples Hospital Cardiology from October 2009 to March 2010. At the same time-line echocardiography, chest X ray and other tests were finished, combined with clinical evaluation of cardiac function in patients with level, defined as heart failure 84 ，and 95 patients without heart failure. The diagnosis of HF was based on （ESC ）standard for HF , combining with echocardiographic evidence of systolic or diastolic dysfunction. Diastolic dysfunction was defined as impaired relaxation or restrictive or pseudonormal pattern. Systolic HF was de