课件：非霍奇金淋巴瘤(NHL).ppt

Peripheral T-cell lymphoma, Unspecified Morphology LN structure is destroyed. The lesion start the paracortex, PCV↑. Neoplastic cell: pleomorphism, invasive growth, nuclear twist. There are many kinds of non-neoplastic reactive cells. Collagen proliferation. Immune phenotype: expression for T cell. Peripheral T-cell lymphoma Peripheral T-cell lymphoma (unspecified) Peripheral T-cell lymphoma (unspecified) Extranodal natural killer/T-cell lymphoma Introduction Originate from: NK cell. Site；2/3 nose↑. Causes: EBV. Characteristics；invasion↑，high malignant. G：the mass obstruct the nasal cavity, bone destruction, intensive hemorrhage and necrosis. M：the neoplastic cells distribute diffusely, different-sized, pleomorphic, destroy the blood vessels. Extranodal natural killer/T-cell lymphoma add：Complications of lymphoma lymphoma invade Compress,invasion marrow spleen immune dysfunction marrow inhibition autoimmune function↓ hemolysis anemia infection Myeloid neoplasm Definition: Arise from hematopoietic stem cells. The non-lymphoctic tumor cells proliferate clonely, and the normal marrow cells are replaced by tumor cells. Four types: Acute myeloblastic leukemia, AML Chronic myeloproliferative disorders, CMPD Myelodysplastic syndromes, MDS MDS/MPD Histocytic neoplasma Definition: Is a proliferative disorder of histocytes and macrophages. Includes: Histocytic lymphoma：malignant Langerhans cell histiocytosis= histiocytosis X eosinophilic granuloma：benign; Hand-Schueler-Christian syndrome：borderline； Letterer-Siwe disease：malignant. Leukemoid reaction Etiology：severe infection, some malignant tumors, drug poison, severe hemorrhage or hemolytic reaction. Manifestation: peripheral blood WBC↑