肝癌治作疗规范内科部分.pptVIP

谢谢! * Two principal mechanisms implicated in hepatocarcinogenesis: Liver cirrhosis following tissue damage Mutations occurring in one or more oncogenic or tumor suppressor genes Dysplastic nodule figures adapted from Tornillo L, et al. Explanation: Quadrant 1: Macroscopic dysplastic nodule Quadrant 2: Low-grade dysplastic nodule in cirrhotic liver Quadrant 3: High-grade dysplastic nodule with pseudoglandular pattern and high nuclear/cytoplasmic ratio Quadrant 4: High-grade dysplastic nodule with preserved reticulin pattern. HCC figures adapted from Dysplasia and Neoplas