Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan a randomised placebo-controlled trial 由受过训练的传统接生员服用米索前列醇预防巴基斯坦家庭分娩中产后出血：一项随机安慰剂对照试验.pdf

DOI: 10.1111/j.1471-0528.2010.02807.x General obstetrics Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial N Mobeen,a J Durocher,b NF Zuberi,c N Jahan,d J Blum,b S Wasim,a G Walraven,a,e J Hatchera a Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan b Gynuity Health Projects, New York, NY, USA c Department of Obstetrics and Gynaecology, Aga Khan University, Karachi, Pakistan d Aga Khan Health Services, Chitral, Pakistan e Delegation of the Aga Khan Development Network Foundation, Aiglemont, Gouvieux, France Correspondence: J Durocher, Gynuity Health Projects. 15 East 26th Street, Suite 801, New York, NY 10010, USA. Email jdurocher@ Accepted 21 October 2010. Published Online 23 December 2010. Objective To determine if misoprostol is safe and efficacious in women receiving misoprostol had a drop in haemoglobin 3 g/dl, preventing postpartum haemorrhage (PPH) when administered by compared with placebo (5.1 versus 9.6%; relative risk 0.53, 95% trained traditional birth attendants (TBA) at home deliveries. CI 0.34–0.83). Shivering and chills were significantly more common with misoprostol. There were no maternal deaths among Design A randomised, double-blind, placebo-controlled trial. participants. Setting Chitral, Khyber Pakhtunkhwa Province, Pakistan. Conclusions Postpartum administration of 600 lg oral Population A total of 1119 women giving birth at home.