巨噬细胞在骨组织修复中的研究进展.PDFVIP

•444 • 45  4 2018  7 国际口腔医学杂志 第 卷 期 年 月 巨噬细胞在骨组织修复中的研究进展 朱宸佑 魏诗敏 汪媛婧 伍颖颖 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科 成都 610041 [摘要] 免疫系统是人体的一道重要防线，参与其中的细胞包括B细胞、T细胞、DC细胞、巨噬细胞等，其中的巨 噬细胞在组织损伤、肿瘤、骨改建等过程中起到尤为重要的作用，随着时间的推移，对于巨噬细胞的了解更为深 入，但巨噬细胞与生物材料之间的应答仍有很多机理尚未明了。因此本综述主要探讨生物材料与巨噬细胞之间的 应答，展望其潜在应用，为基础及临床研究提供新思路。 [关键词] 巨噬细胞； 骨组织修复； 牙种植； 引导性骨再生 [中图分类号] Q 813 [文献标志码] A [doi] 10.7518/gjkq.2018.04.013 Research progress on macrophage in bone tissue repair Zhu Chenyou, Wei Shimin, Wang Yuanjing, Wu Yingying. (State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) This study was supported by Program for Sichuan University Excellent Young Scholars Research Fund (2017SCU04A21), Sichuan Provincial Department of Science and Technology Talent Project (2018RZ0088), and Sichuan University Innovation and Entrepreneurship Training Program under Grants (C2018103082). [Abstract] The immune system is an important barrier for defense in the human body. This system includes B cells, T cells, dendritic cells (DC), and macrophages, which play a pivotal role in tissue injury, tumor, and bone remodeling. The understanding of macrophages has improved in the past years, but numerous mechanisms between macrophages and biomaterials remain largely unknown. Thus, the present study discusses the response between macrophages and biomaterials and predicts their potential application to provide new ideas for basic and clinical research. [Key words] macrophage; bone repair; dental implant; guided bone regeneration 随