课件：女性常见疾病防治.ppt

主要经营：网络软件设计、图文设计制作、发布广告等 公司秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 * 大家 XXX 好！ 谢谢， Dr. Liu 邀请我来参加这次学习班。 刚才介绍了我的情况， 我讲的题目是….. * . * As you can see on this slide, there are several known risk factors that influence one’s likelihood of being infected with Human papillomavirus and of progressing to cervical cancer. Of special importance is: (1) HPV positively and specific type; Anogenital-specific HPV types can be classified as either “low risk”, meaning non-cancer associated, or “intermediate/high risk” - often termed the carcinogenic HPVs. This later group has the potential to promote progression to cervical cancer. (2) Persistent HPV infection; While most HPV infections are transient, evidence suggests that carcinogenic types persist longer, thereby increasing a woman’s risk of progressing to HSIL. Women with invasive cancer have the same HPV type as those with HSILs, except that they are on average a decade older.4 Carcinogenic HPV types in women approximately 35 years of age are likely to reflect persistent, high-risk infections.5 * Next, we examine the progression of HPV infection to cervical cancer. After exposure to HPV, events in the viral life cycle are initiated, with specific activity regulated by the factors responsible for the host’s immune response. HPV infection alone is not sufficient to induce an immediate carcinoma because malignant tumors develop only after HPV-induced lesions persist for several months or even years. There is a large reservoir of HPV infection in young women in their teens and twenties. Only a few of these women go on to develop persistent HPV infection. Progression depends on viral type, immunologic factors and possibly co-carcinogens. Persistent high-risk infections can lead to cellular deregulation. Over time, this cellular deregulation can cause high-grade cervical lesions and ultimately, cervical cancer. Oncogenic activity has been attributed to the viral oncoprote