基于信息熵赋值法的正交联用Box-Behnken设计-响应面法优化黄丝郁.PDF

中草药 Chinese Traditional and Herbal Drugs 49 8 2018 4 1823 Box-Behnken - 1 1 1, 4 1 2, 3 1, 2* 权 亮 ，赵永峰 ，陈志敏 ，周海婷 ，李文兵 ，胡昌江 1. 611137 2. 611900 3. 611900 4. 610016 Box-Behnken -BBD-RSM HPLC BBD-RSM 10%10 min130 10 minBBD-RSM 12 min 150 8 min Box-Behnken - R283.1 A 0253 - 2670(2018)08 - 1823 - 06 DOI: 10.7501/j.issn.0253-2670.2018.08.013 Optimization of processing technology of stir-frying with vinegar of Curcuma Longa Radix by orthogonal design and Box-Behnken design-response surface based on entropy method 1 1 1, 4 1 2, 3 1, 2 QUAN Liang , ZHAO Yong-feng , CHEN Zhi-min , ZHOU Hai-ting , LI Wen-bing , HU Chang-jiang 1. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China 2. Key Laboratory of Chinese Medicine Formulations Particle Mass and Clinical Evaluation, State Administration of Traditional Chinese Medicine, Chengdu 611900, China 3. Neo-Green Pharmaceutical Co., Ltd., Chengdu 611900, China 4. Chengdu Institute of Chinese Herbal Medicine, Chengdu 610016, China Abstract: Objective To optimize the processing technology of stir-frying with vinegar of Curcuma Longa Radix (CLR) by orthogonal design and Box-Behnken design-respanse surface method (BBD-RSM) based on entropy method. Methods As comprehensive evaluation indexes, the contents of curcumin, demethoxycurcumin, and bisdemethoxycurcumin in CLR processed by traditional method were determined by HPLC. The orthogonal test was adapt