抗体结构的介绍.pdfVIP

z z Ø PorterIgGIg z N CIL C ) H z 1.light chainL 21424kD LKappa k lamnda λ 2 2.heavy chainH 450~55055~75kD 4~55μ γ αδεH Lkλ IgIgMIgGIgAIgD IgE z z § HL § N-V § C-C z Variable regionV LN1/2VL 108-111HN1/5~1/4VH 118V 65~75 z hypervariable regionHVR)framework regionFRVL HVR24~3450~5689~97VH HVR 31~3550~5695~102VLVH HVR1HVR2 HVR3. z complementarity-determining regionCDR VLVH HVR1HVR2HVR3CDR1,CDR2,CER3, CDR3H z constant regionC § LC 1/2105HC 3/4~4/5331~431 § z domain 110 1L2VL CL 2 HIgGIgAIgD4V 1C3IgMIgE5V 1C4) 3βLHV Cβ z 4 1VLVH 2 CLCH1 3 IgGCH2IgMCH3C1qIgGCH2 4 CH3CH4BNKFc 5 1CH1CH2H α- 2 22 3 CH2CH3 4 z § 1 § 1959PorterPapainIgGIgGN 2Fab1Fc Fabfragment antigen bindingFabL HN1/2Fab Fab1/2H Fd225VH CH1Fc fragment crystallizableFcFc HCCH2CH3 IgFcduanFc z § 2 § 1960NisonoffIgGIgG C1FabF ab