5支架XiencePRIME.ppt

支架平台：发展史 DES支架壁厚度 临床前研究结果 Xience PRIME设计目标 XIENCE PRIME  MULTI-LINK系列支架在设计上的持续创新 XIENCE PRIME支架设计改进的MULTI-LINK设计，提高了输送性 ?2011 Abbott. All rights reserved. AP2934329 Rev. D. Information contained herein intended for healthcare professionals from geographies outside the U.S. and Japan only. Let’s discuss the components of the XIENCE family that have been demonstrated to have superior outcomes in the SPIRIT family of clinical trials. The drug and drug dose of XIENCE V and XIENCE PRIME are the same with the proven drug Everolimus at the same low, efficacious dose of 88 ug for a 3.0 x 18 mm stent size. The same highly biocompatible fluorinated copolymer controls the drug elution, and is the same thickness between XIENCE V and XIENCE PRIME. Finally, the stent platform is the same, utilizing the same, proven MULTI-LINK stent design that was introduced with the original MULTI-LINK in 1997 and proven Cobalt Chromium stent alloy that Abbott Vascular introduced in 2003. MULTI-LINK 8 is the latest generation of the MULTI-LINK family, featuring an enhanced stent design compared to MULTI-LINK VISION for improved flexibility. DES的设计 药物 作用机制 治疗窗 载药量 稳定性 支架和输送系统 （支架平台） 支架壁厚度 结构性支撑 顺应性 球囊头端 跟踪性 聚合物 生物相容性 机械完整性 聚合物厚度 药物释放曲线 MULTI-LINK 市场占有率 第一 1997 MULTI-LINK TRISTAR 市场占有率 第一 1999 MULTI-LINK TETRA 市场占有率 第一 2000 MULTI-LINK PENTA 市场占有率 第一 2001 MULTI-LINK ZETA 市场占有率 第一 2002 MULTI-LINK VISION 市场占有率 第一 2003 MULTI-LINK 81 最新 2009 MULTI-LINKDUET 市场占有率 第一 1998 环和环为平行的正弦波形，由规律分布的 Link 相连 ? 3-3-3 连接 弯曲连接 ? 3-3-3 连接 弯曲连接 ? 3-3-3 连接 弯曲连接 钴铬合金 ? 3-3-3 连接 弯曲连接 钴铬合金 ? 3-3-3 连接 ? 3-2-3 连接 ? 3-2-3 连接 ? 3-3-3 连接 1. MULTI-LINK 8 is the bare metal platform for XIENCE PRIME. 支架平台对再狭窄的影响 支架壁厚度与再狭窄 支架壁厚度与内皮化 R. Virmani, TCT 2008 XIENCE PRIME 支架梁厚度: 81 μm 合金: 钴铬合金 聚合物厚度: 7.8 μm ENDEAVORRESOLUTE 91 μm 合金: 钴镍合金 聚合物厚度: 6.2 μm PROMUSELEMENT 81 μm 合金: 铁铂合金 聚合物厚度: 7.8 μm CYPHER 140 μm 合金: 聚合物厚度: 12.6 μm 316L 不锈钢 3.0 mm diameter stents, 500 x magnification. Photos taken by and data