缺血后适应在临床中的应用及研究进展-中国动脉硬化杂志.PDF

CN43鄄1262/ R摇 中国动脉硬化杂志2013年第21卷第5期 477 [文章编号]摇 1007鄄3949(2013)21鄄05鄄0477鄄04 ·文献综述 · 缺血后适应在临床中的应用及研究进展 1 2 张苗苗 ,王贵松 (1.煤炭总医院心血管内科,北京市 100028;2.北京大学第三医院心内科,北京市 100191) [关键词]摇 心肌梗死;摇 缺血后适应;摇 缺血再灌注;摇 再灌注损伤 [摘摇 要]摇 缺血后适应对缺血再灌注损伤的心肌具有降低梗死面积,减少细胞凋亡及改善内皮功能等保护作用。 后适应在临床应用中的可操作性,使其成为近年来心血管研究领域中的重点和热点。 本文就缺血后适应在临床中 的应用及研究进展做一综述。 [中图分类号]摇 R54 [文献标识码]摇 A Clinical Application and Study Progress of Myocardial Ischemic Postconditioning 1 2 ZHANG Miao鄄Miao ,and WANG Gui鄄Song (1.Cardiovsacular Department,China Coal General Hospital,Beijing 100028,China;2. Department of Cardiology,the Third Hospital of Peking University,Beijing 100191,China) [KEY WORDS]摇 Myocardial Infarction;摇 Ischemic Postconditioning;摇 Ischemia鄄Reperfusion;摇 Reperfusion Injury [ABSTRACT]摇 Ischemic postconditioning had been observed to reduce infarct size and cell apoptosis on myocardial is鄄 chemia鄄reperfusion injury,andwas also associated with a reduction in endothelial cell dysfunction and so on. Postcondi鄄 tioning is afairly simplestrategy,andseemspossibletobeappliedinpatients. Wewillreviewtheadvancementsofprotec鄄 tive effects and the mechanismsin myocardial ischemicpostconditioning. Theoperability of postconditioning in clinical ap鄄 plication makes it thefocus and hotspots in thefieldof cardiovascular research inrecentyears. Wewill review the clinical application and study progress of myocardial ischemic postconditioning. 摇 摇 早期再灌注治疗如溶栓和直接经皮冠状动脉介 1摇 缺血后适应的保护机制 入(percutaneous coronary intervention,PCI)治疗能够 有效地恢复心肌血流灌注,