病毒性肝炎抗病毒治疗进展.ppt

* * Clearly you all recognise the above but it is important to put our discussions into perspective of the need for when to treat and what to prevent. For all those who do get infected 10% become chronic and it is from this group that become chronic that we ideally need a treatment. It is a long-term disease so earlier treatment maybe useful. * 慢性HBV携带者：约1/4可能转成乙肝病人；约1/5肝穿刺证实肝组织仍有炎症（仍有可能发展为慢肝、肝硬化、肝癌） * * 对达不到上述治疗标准、但有以下情形之一者，亦应考虑给予抗病毒治疗 动态观察发现持续HBV DNA阳性、ALT大于正常上限且年龄大于40岁者，也应考虑抗病毒治疗。 对ALT持续正常但年龄较大者（40岁），应密切随访，最好进行肝活检；如果肝组织学显示Knodell HAI ≥4，或炎症坏死≥G2或≥纤维化S2，应积极给予抗病毒治疗。 动态观察发现有疾病进展的证据（如脾脏增大）者，建