NLRP3炎症小体调控机制研究进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 16, 51 ( 10): 1505 1512 ·1505 · ·综述· NLRP3 症小体调控机制研究进展 雯, 郭文洁, 徐 强, 孙 洋* (南京大学生命科学学院, 医 生物技术国家重点实验室, 江苏 南京 210023) 摘要: 炎症小体活化是由多蛋白复合物组装信号介导的炎症相关的半胱氨酸天冬氨酸特异蛋白酶 (caspase) 活化以及白细胞介素-1 (interleukin-1 , IL-1 ) 、白细胞介素- 18 (interleukin-18, IL-18) 等炎症因子的成熟过程。其 中NOD (nucleotide binding oligomerization domain) 样受体家族3 (NOD-like receptors, NLRP3) 炎症小体是目前 研究最透彻的炎症小体类型, 它参与了人类众多疾病的发生发展。因此靶向NLRP3 炎症小体已经成为相关疾病 治疗药物开发的热点。本综述总结了近5 年来关于NLRP3 炎症小体的研究进展, 包括NLRP3 priming 阶段的调 控、蛋白复合物组装的调控、内源性代谢物质及亚细胞器对NLRP3 的活化调节及小分子抑制剂的研究。对NLRP3 调控机制的深入认识将有助于新药物靶标发现和治疗药物的开发。 关键词: 炎性疾病; NLRP3 炎症小体; 白介素-1 ; 调控 中图分类号: R965 文献标识码: A 文章编号: 0513-4870 (20 16) 10- 1505-08 Advances in mechanisms for NLRP3 inflammasomes regulation * LIU Wen, GUO Wen-jie, XU Qiang, SUN Yang (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanj ing University, Nanj ing 210023, China ) Abstract : Activation of inflammasomes involves multi-protein assembly and activation of inflammatory caspase and maturation of pro-inflammatory cytokines interleukin-1 (IL-1 ) and interleukin-18 (IL-18). Among those types of inflammasomes, NOD (nucleotide binding oligomerization domain)-like receptors (NLRP3) is the most studied inflammasome which involves in amount of human inflammatory and autoimmune diseases. Therefore, targeting on NLRP3 inflammasome has been one of the promising methods for treatment of diseases. In this review, we focused on the studies in the latest five years on the mechanisms of NLRP3 in