课件：调脂防治冠心病现状与展望.pptVIP

主要经营：课件设计，文档制作，网络软件设计、图文设计制作、发布广告等 秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 * 脂蛋白滞留-应答学说认为，动脉粥样硬化（AS）的发生起始于含载脂蛋白B（apoB）的脂蛋白（主要是LDL）滞留粘附于内皮下，在细胞外基质分子的作用下发生氧化修饰，诱发局部以炎症反应为主的生物学反应，并刺激来源于循环血中的单核细胞转化为巨噬细胞，后者大量吞噬修饰后的LDL转化为泡沫细胞。经过这种局部非适应性炎症反应，进一步促进了脂蛋白的滞留和病变进展[2]。脂蛋白滞留-反应学说的提出和发展是人们对动脉粥样硬化发病机制的新认识，也为疾病的早期干预提供了新的靶点。 * 给新西兰兔静脉注射LDL后，血脂水平急剧升高，最早检测到的动脉壁的变化（2小时内）也是动脉壁内LDL及LDL微团聚体的滞留。 * Representative histology of deposited lipids and infiltrating macrophages in the arterial wall. a, b, and c, Grade 0, DIT, 36 years of age, male. d, e, and f, Grade 1, fatty streak, 32 years of age, male. g, h, and i, Grade 2, fatty streak, 39 years of age, female. j, k, and l, Grade 2, fatty streak, 44 years of age, male. The total lipid density was greater in this case than the case of Figure g, h and i. m, n, and o, Grade 3, PIT, 49 years of age, male. An accumulation of lipid-laden (but not foamy) macrophages was seen in the upper to middle layer of the intima. p, q, and r, Grade 3, PIT with foam cells, 29 years of age, male. Foam cells with clear cytoplasm in EVG stained section and abundant intracellular lipids in Sudan IV stained section were accumulated in the upper to middle layers of the intima. a, d, g, j, m, and p, EVG stain. I indicates intima; M, media. b, e, h, k, n, and q, Sudan IV stain. c, f, i, l, o, and r, Immunostaining with anti-CD68 antibody. Arrowheads indicate internal elastic lamina. Bars represent 100 μm. DIT indicates diffuse intimal thickening; PIT, pathologic intimal thickening. Nakashima[5]等对非心源性死亡的儿童与青年人进行尸检后发现了右冠状动脉易损区血管内皮的变化谱：描述了早期AS病变进展的过程，精确印证了AS发生发展的滞留-反应模型。 早期，在富含蛋白多糖的弥漫性内膜增厚(DIT)区域并没有脂质滞留和巨噬细胞浸润。 脂质滞留于内膜下，且早于巨噬细胞浸润。 之后，巨噬细胞浸润，脂质滞留和巨噬细胞浸润增加，直至泡沫细胞形成。 * 脂蛋白的蛋白成分（尤其是apoB）带正电荷区域与蛋白聚糖带负电荷的糖基基团相互作用。进一步研究提示，蛋白聚糖中包含硫酸软骨素的侧链在脂蛋白滞留、特别是早期AS中起着尤为关键的作用 * All three efficacy parameters using IVUS showed statistically significant regression. Percent Atheroma Volume and Normalised Total Atheroma Volume relate to the total art