电纺载药纳米纤维改善难溶药物溶解性能研究Theimprovementof.PDF

药学学报 Acta Pharmaceutica Sinica 2009, 44 ( 10) : 1179 1182 ·1179 · ·研究简报· 电纺载药纳米纤维改善难溶药物溶解性能研究 1 1 1 2 1* 余灯广 , 张晓飞 , 申夏夏 , Branford-White Chris , 朱利民 ( 1. 东华大学化学化工与生物工程学院, 上海 20 1620; 2. 伦敦都市大学卫生健康与政策研究所, 伦敦) 关键词: 电纺; 纳米纤维; 难溶药物; 聚乙烯吡咯烷酮; 速溶 中图分类号: R943; O646 文献标识码:A 文章编号: 0513-4870 (2009) 10-1179-04 The improvement of poorly water-soluble drug solubility through electrospun drug-loaded nanofibers 1 1 1 2 1* YU Deng-guang , ZHANG Xiao-fei , SHEN Xia-xia , BRANFORD-WHITE Chris , ZHU Li-min (1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; 2. Institute for Health Research and Policy, London Metropolitan University, London, UK) Abstract: The improving effect of electrospun drug-loaded nanofibers on the solubility of poorly water- soluble drug was investigated in the present research. Drug-loaded nanofibers were successfully prepared using electrospinning process with helicid as the poorly water-soluble model drug and polyvinylpyrrolidone K60 (PVP K60) as the filament-forming matrix. Scanning electron microscopy observation demonstrated that the nanofibers had a three-dimensional continuous web structure, and had well smooth surface and a diameter between 400 600 nm. X-ray diffraction results suggested that helicid lost its original crystal structure but highly distributed into the nanofibers in an amorphous state, resulting from the hydrogen bonding interactions between the carboxylic group of PVP K60 and the hydroxyl groups of helicid. T