基于Mn掺杂ZnS量子点温室磷光检测左氧氟沙星.pdfVIP

第46卷第9期 应　 用　 化　 工 Vol.46 No.9 2017年9月 Applied Chemical Industry Sep.2017 基于Mn掺杂ZnS量子点温室磷光检测左氧氟沙星 安昭琦,栗东霞,闫桂琴 (山西师范大学 生命科学学院,山西 临汾　 041000) 摘　 要:以3-巯基丙酸为稳定剂,采用水相合成法制备 Mn掺杂ZnS量子点,由于左氧氟沙星(LVFX)的3-羰基与 Mn掺杂ZnS量子点表面的二价金属离子形成配合物,使得Mn 掺杂ZnS 量子点发生温室磷光猝灭效应,从而构建 了一种快速、灵敏检测人体体液中LVFX 的新方法。 在最佳条件下(pH7.4,反应时间10 min),其线性关系△RTP =27.56c(LVFX)+52.002(R =0.995),线性范围0.5 ~100 μmol/ L,检出限0.35 μmol/ L,加标回收率96.2% ~ 104.6%,可用于LVFX注射液与人体尿液中LVFX 的快速测定。 关键词:Mn掺杂ZnS量子点;温室磷光;左氧氟沙星 + 中图分类号:TQ034;TQ420.7 11;O657.3　 　 文献标识码:A　 　 文章编号:1671-3206(2017)09-1839-05 Detection of Levofloxacin by room temperature phosphorescence method based on Mn doped ZnS quantum dots AN Zhao-qi,LI Dong-xia,YAN Gui-qin (College of Life Science,Shanxi Normal University,Linfen041000,China) Abstract:By taking 3-mercaptopropionic acid (MPA) as the stabilizer and preparing Mn doped ZnS quantum dots (QDs) by means of water phase synthesis method,room temperature phosphorescence quenching effect was happened to the Mn doped ZnS quantum dots because of the coordination complex formulated by bivalent metal ions on the surface of 3-carbonyl in Levofloxacin (LVFX) and Mn doped ZnSquantumdots,thus,anew rapidandsensitivemethodtodetect LVFXinhumanbodyfluidwasdevel- oped.Under optimum conditions (pH7.4,reaction time 10 min),with a linear relationship of △RTP= 27.56c(LVFX)+52.002(R =0.995),linear scope of 0.5 ~100 μmol/ L,and the detection limit and standard additionrecovery of0.35 μmol/ Land96.2% ~104.6%,respectively,thismethod can beused for rapid detection of LVFX injection and LVFX in human urine. Key words:Mn doped ZnS quantum dots;room t