亚裔高发鼻咽癌的遗传学特征与华人易感性解析-同昕生物技术.PDF

Chinese Journal ofNew Drugs 2008, Vol. 17No. 3 2008 17 3 , ,, (首都医科大学化学生物学与药学院, 北京 100069) [] 世界上 80% 的鼻咽癌患者在中国, 鼻咽癌的流行病学和分 生物学显示的华人易感性使与鼻 咽癌相关的研究在发达的工业国家相对被忽略作为华人易感性恶性肿瘤, 鼻咽癌给我国局部地区的居民 带来了严重危害文中主要针对鼻咽癌作为一种多基因遗传性肿瘤发病的遗传学基础进行综述包括鼻咽 癌流行病学分 生物学和细胞遗传学特征与华人易感性分析, 为抗鼻咽癌药物的研发打下基础 [] 鼻咽癌; 遗传特性; 华人易感性 [] R968; R739. 63 [] A [] 1003- 3734( 2008)03- 0186- 05 M echan ism of nasopharyngeal carcinom a and pharm acogenom ics in research study CUI Chunying, Z AO M ing, CU IGuohu,i PENG Shiqi (School of Chem icalB iology and Pharmaceutical Sciences, Cap italM edical University, Beijing 100069, China) [ A bstract] 80% nasopharyngealcarcinoma (NPC) patients areChinesepeople, epidem iology andmolecu lar biology ofNPC showed that theNPC related research was ignored in thewestern country because of low inci dence of a disease. As amalignant disease of the head/neck region which is endemic in SouthEastAsia, NPC mainly affects young patients in their40- 50s and brings serious influence. Wew ill review the pharmaceuticaland pharmacogenomical research on NPC including epidemiology, molecular biology and Chinese susceptibility, in or der to put the basis for the antiNPC drug development in future. [ Key w ord s] nasopharyngeal carcinoma; pharmacogenom ics; Chinese susceptibility , , // 3. 42. 21 ! 1966- 1986 20, , , , [ 1~ 4] 80%,