维生素胶囊对大鼠试验性高脂血症防治作用的研究.doc

PAGE PAGE 7 一种大蒜粉-维生素胶囊对大鼠实验性高脂血症防治作用的研究 郭浪1 王喜云2 张广求3 (1湖南化工职业技术学院 湖南株州 412002 湖北省十堰市疾病预防控制中心 湖北十堰 442000 3云南民族大学 云南昆明 650031） 摘 要： 目的 研究大蒜粉-维生素胶囊（大蒜粉、维生素C、维生素E等）对大鼠实验性高脂血症血清的调节作用。 方法 将48只健康雌性SD大鼠按体重和血清胆固醇水平随机分成6组，正常对照组喂食基础饲料，其余5组喂食高脂饲料，低、高剂量预防组同时每天灌喂胶囊粉，低、高剂量高脂组则在喂食一周高脂饲料后再开始每天灌喂胶囊粉；低、高剂量分别为100mg/kg和200mg/kg。5周结束，测定血清胆固醇（TC），甘油三酯（TG），高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（ LDL-C）和动脉粥样硬化指数（AI）。结果 四个受试物组大鼠血清中的 TC、TG、LDL-C和AI水平都低于高脂模型组，其中高剂量组具有显著性（P＜0.05）差异。结论 大蒜粉-维生素胶囊对实验性大鼠的高脂血症具有良好的辅助防治作用。 关键词：大蒜粉-维生素胶囊 血脂 辅助防治作用 Study of the preventive and therapeutic effects of garlic powder-vitamin capsule on serum lipids of experimental hyperlipidemia rats GUO Lang1 WANG Xiyun2 ZHANG Guang-qiu3 (1Hunan Chemical Industry and Vocation Technology College, Zhuzhou 412002 2Center for disease control and prevention Shiyan 442000 Yunnan Nationalities University, Kunming 650031) 作者简介: 郭浪 (1974- )，男，硕士,讲师，主要从事天然药物与保健品的研发。E-mail:2003gl@ ABSTRACT: OBJECTIVE To study the lipid-lowering effects of garlic powder-vitamin capsule composed of garlic powder, VC and VE, et al. METHODS 48 female SD rats were randomly divided into 6 groups according to body weight and serum cholesterol levels.Rats in control group were fed reference diet and the others were fed high fat supplemented diet. Rats in two preventive groups were simultaneously fed powder of capsule and rats in two high-fat groups were fed it after 1 week. The low dose was 100mg/kg and the high was 200mg/kg. After 5 weeks, serum total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were determined. RESULTS The serum TC,TG, LDL-C and atherosclerotic index(AI) levels of rats in four examined groups were all decreased comparing with the high fat model group.The high dose groups were significant(P＜0.05). CONCLUSION The garlic powder-vitamin capsule has some adjuvant preventive and therapeutic effects on serum lipids of experimental hyperlipidemia rats. KEY WORDS