肺内磨玻璃影的分子生物学研究进展-中国癌症杂志.PDFVIP

中国癌症杂志 2014年第24卷第3期 《 》 CHINA ONCOLOGY 2014 Vol.24 No.3 235 肺内磨玻璃影的分子生物学研究进展 乔文亮 综述　林强 审校 上海交通大学附属第一人民医院胸外科，上海 200025 　　［摘要］　近年来，低剂量CT广泛应用于早期肺癌的筛查，肺内磨玻璃影(ground-glass opacity，GGO) 的检出率逐渐升高。多数学者认为它与早期肺腺癌密切相关，其定性诊断和早期治疗对于提高早期肺癌患者的 诊断率与生存率具有重要意义。关于GGO的影像学诊断、定位方法及手术方式进展国内外已有许多报道，现重 点将近年来与其分子生物学方面相关的研究进展综述如下。 　　 ［关键词］　肺内磨玻璃影；染色体；表皮生长因子受体基因；CYFRA21-1蛋白；实时定量PCR 　　DOI: 10.3969/j.issn.1007-3969.2014.03.014 　　中图分类号：R734.2　　文献标志码：A　　文章编号：1007-3639(2014)03-0235-06 Research progress of molecular biology in ground-glass opacity QIAO Wen-liang, LIN Qiang (Department of Thoracic Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200025, China) Correspondence to: LIN Qiang E-mail: xklinqiang@ 　　［Abstract ］ With the low-dose spiral computed tomography (LDCT) widely applied in screening for early- stage lung cancers recently, positive rates of Ground-Glass Opacity (GGO) are gradually increased. Many professional researchers believe GGO has a close relationship with the early-stage lung adenocarcinoma, consequently, qualitative diagnosis and early treatment of GGO plays a significant role in improving the diagnostic and survival rates of patients with early-stage lung cancer. Since relative imaging diagnosis, location methods and surgical approaches of GGO have been reported a lot by domestic and overseas researchers, our reviews would mainly focus on the diverse research progress of molecular biology of GGO in the past several years. 　　［Key words ］ Ground-glass opacity; Chromosome; EGFR gene; CYFRA21-1 protein; Real-time PCR 6 (ground-glass opacity GGO) pGGO) (mix