IGFs在骨肉瘤发生发展及治疗中的作用-肿瘤药学.PDFVIP

- 668 - 肿瘤药学 2018 年 10 月第 8 卷第 5 期　Anti-tumor Pharmacy, October 2018, Vol. 8, No. 5 ●综　　述● IGFs 在骨肉瘤发生发展及治疗中的作用★ 陈柳含 ，李先安* （湖南省肿瘤 医院/ 中南大学湘雅 医学院附属肿瘤 医院，湖南 长沙，4 100 13 ） 摘要：骨肉瘤发病机制极其复杂，目前尚未明确。研究表明胰岛素样生长因子家族（IGFs）在骨肉瘤的发生发展中有重要 作用。IGF-1、IGF-2 高表达与骨肉瘤的发生呈正相关，IGF-IR 相关的异常信号通路参与骨肉瘤的发生和发展，IGF-IR 也 与骨肉瘤的不良预后密切相关，IGF-1R 表达水平越高，提示预后越差。IGF 家族中其它成员如 IGF-2R、IGFBP 等均被证实 参与了骨肉瘤的发生发展。近年来，以 IGF-1R 为主的靶向治疗在骨肉瘤辅助治疗中初见成效，各期临床试验正在稳步进行， 但确切的临床疗效还有赖于对 IGFs 和骨肉瘤的更进一步研究和探索。本文对 IGFs 在骨肉瘤的发生发展及治疗中的相关作用 进行综述。 关键词：骨肉瘤；IGFs 中图分类号：R738.1　文献标识码 ：A　文章编号：2095-1264（2018）05-0668-07 doi：10.3969/j.issn.2095-1264.2018.05.03 The Role of IGFs in the Development and Treatment of Osteosarcoma ★ * CHEN Liuhan, LI Xian an (Hunan Cancer Hosp ital / The Aff iliated Cancer Hosp ital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China) Abstract: The pathogenesis of osteosarcoma is extremely complex and still remains unclear. It has been shown that IGFs play an impor- tant role in the development of osteosarcoma. The high expression of IGF-1 and IGF-2 are positively correlated with the occurrence of the tumor. IGF-IR related signaling pathways are also involved in the development of osteosarcoma. It is suggested that the poor prognosis may be associated with IGF-1R, the higher the expression of IGF-1R is, the worse the prognosis of the tumor is. Other members of the IGF fam- ily, such as IGF-2R and IGFBP, have also been proved to contribute to the tumor ’s growth. In recent years, targeted therapy based on IGF- 1R has achieved initial results in the adjuvant treatment of osteosarcoma. However, the exact clinical effect depends on the further