微流控芯片在中枢神经系统疾病中的应用与展望.PDFVIP

396 生 物 工 程 学 报 赵晨羽 等/微流控芯片在中枢神经系统疾病中的应用与展望 Chinese Journal of Biotechnology /cjbcn Mar. 25, 2019, 35(3): 396−403 DOI: 10.13345/j.cjb.180291 ©2019 Chin J Biotech, All rights reserved ·综 述· 赵晨羽，陈峰 浙江工业大学 生物工程学院，浙江 杭州 310032 赵晨羽, 陈峰. 微流控芯片在中枢神经系统疾病中的应用与展望. 生物工程学报, 2019, 35(3): 396–403. Zhao CY, Chen F. Application and prospect of microfluidic chip in central nervous system diseases. Chin J Biotech, 2019, 35(3): 396–403. 摘 要: 近年来，随着微流体技术和生物微电子机械系统技术的不断发展，人类中枢神经系统 (CNS) 的微流体 平台及相关疾病的体外模型逐渐得到了广泛的研究。微流体平台可以更好地模拟体内环境，同时能够控制结构、 微环境和外来刺激。文中总结了微流控芯片在 CNS 的基本技术和CNS 疾病中的应用。此外，文中对微流控芯片 在CNS 中的研究进行了展望，强调了通过跨学科的共同努力能够实现更高程度的仿生学挑战。 : 微流体技术，中枢神经系统，疾病模型，微流控芯片 Application and prospect of microfluidic chip in central nervous system diseases Chenyu Zhao, and Feng Chen College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, Zhejiang, China Abstract: In recent years, many human central nervous systems (CNS) of microfluidic platforms and related disease models in vitro have been built with the continuous development of the microfluidic technology and biological microelectronics mechanical systems technology. Microplatforms have emerged to provide a better approximation of the in vivo scenario with better control of the structure, microenvironment and stimuli. This review summarized the basic technology of microfluidic chips in CNS and the application in CNS diseases. In addition, the research of microfluidic chip in CNS diseases has been also prospected. We also highlight challenges that can be address