替吉奥胶囊联合同步放疗治疗晚期胃癌的临床研究.docxVIP

替吉奥胶囊联合同步放疗治疗晚期胃癌 的临床研究 穆克代斯?伊力亚斯 巴尔夏古丽?扎比胡拉 伊斯 刊达尔?阿布力米提 新疆医科大学附属肿瘤医院胸腹放疗科 摘要： 目的观察替吉奥胶囊联合同步放疗治疗晚期胃癌的临床疗效和安全性。方法将 92例晚期胃癌患者随机分为对照组46例和试验组46例。对照组予以同步放疗, 每周5次;试验组在对照组治疗的基础上，予以40 mg - m-2替吉奥，早晚各1 次，口服，连服14 d后停药7 do 2组患者一个疗程21 d,共治疗2个疗程。 比较2组患者的临床疗效和药物不良反应的发生情况。结果治疗后，试验组和 对照组的总有效率分别为67. 39% （31例/46例）和45.65% （21例/46例）,1 年存活率分别为69. 57% （32例/46例）和45. 65% （21例/46例）,差异均有统 计学意义（均P0. 05）。试验组和对照组的III级恶心呕吐发生率分别为2. 17% 和15. 22%, I 级转氨酶升高发生率分别为17. 39%和36. 96%, III级白细胞减少 发生率分别为10. 87%和39.13%,差异均有统计学意义（均P0. 05）。结论替 吉奥胶囊联合同步放疗治疗晚期胃癌的临床疗效显著，且安全性较好。 关键词： 替吉奥胶囊;放疗;胃癌;安全性; 作者简介：穆克代斯?伊力亚斯（1976-），女，主治医师，主要从事胸腹肿瘤 放射治疗工作 作者简介：伊斯刊达尔?阿布力米提，主任医师，硕士生导师 MP~mai1:shaowen_zhang@126. com 收稿日期:2017-06-21 Clinical trial of tegafur gimeracil and oteracil potassium capsules combined with radiotherapy in the t rea tment of advanced gas trie cancer MUKEDAISI ? Yiliyasi BAERXIAGULI ■ Zabihula YISIKANDAER ? Abulimiti Department of Thoracic and Abdominal Radiation, Aff订iated Tumor Hospital, Xinjiang Medical University; Abstract： Objective To observe the clinical efficacy and safety of tegafur gimeracil and oteracil potassium capsules combined with radiotherapy in the treatment of advanced gas trie cancer. Me thods A total of 92 patients with advanced gastric cancer were randomly divided into control group and treatment group with 46 cases per group.Control group received radiotherapy, five times a week. Treatment group was given 40 mg ? m-2 tegafur gimeracil and oteracil potassium capsules, every morning and night, orally for 14 day and stop for 7 days, on the basis of control group. Two groups were treated for 2 cycles with 21 d per cycle. The cl inical efficacy and adverse drug reactions were compared between two groups. Results After treatment, the total effective rates in the treatment and control groups were 67.39% (31 cases/46 cases) and45. 65% (21 cases/46 cases) , the 1-year survival rates in the treatment and control groups were 69. 57% (32 cases/46 cases) and 45.65% (21 cases/46 cases