1 褪黑素和银杏叶提取物 对大鼠记忆影响.pdfVIP

Life Sciences 71 (2002) 2625–2631 /locate/lifescie The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with h-amyloid 1–40 * 1 2 F. Tang , S. Nag , S.Y.W. Shiu, S.F. Pang Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Received 11 March 2002; accepted 3 June 2002 Abstract Intraventricular infusion of rats with h-amyloid for 14 days resulted in memory deficit in the water maze as well as decreases in choline acetyltransferase activities and somatostatin levels in the cerebral cortex and hippocampus. These changes were not altered by daily intraperitoneal injection of 20 mg/Kg melatonin. Orally administered Ginkgo biloba extract, however, partially reversed the memory deficit and the decrease in choline acetyltransferase activities in the hippocampus. The latter treatment failed to reverse the decrease in somatostatin levels. The results indicate that orally administered Ginkgo biloba extract can protect the brain against h-amyloid-induced changes which lead to memory deficit through its effect on the cholinergic system. D 2002 Elsevier Science Inc. All rights reserved. Keywords: Cholinergic; Ginkgo biloba; melatonin; somatostatin; water-maze Introduction In our previous studies, intracerebroventricular (i.c.v.) infusion of rats with h-amyloid for 14 days results in memory deficit in the Morris water maze as well as decreases in choline acetyltransferase * Corresponding author. Tel.: +852-