含吲哚或异喹啉DNA靶向分子合成及活性研究-精细化工专业论文.docx

含吲哚或异喹啉DNA靶向分子合成及活性研究Synthesis 含吲哚或异喹啉DNA靶向分子合成及活性研究 Synthesis and Biological Evaluation of DNA—targeted Drugs Containing Indole and Isoquinoline Groups Abstract According the design thought of molecular hybridization，this article choose indole or isoquinoline as pharmacophores to decorate different DNA intercalators to design and synthesis three novel series DNA．targeted anticancer drugs．Their molecular structures were confirmed，and their spectral properties combining with DNA and anti-IUlTIOr abilities were evaluatd． Based on the bioactivity of 9．1 O-phenanthrenequione and the anti—tunlor ef