脑神经保护剂治疗脑外伤的临床疗效及其安全性.docxVIP

脑神经保护剂治疗脑外伤的临床疗效及 其安全性 李利博张文佳 湖南中医药大学第一附属医院神经外科 摘要： R的探讨脑昔肌肽注射液与单唾液酸四己糖神经节昔脂钠注射液治疗脑外伤的 临床疗效及其安全性。方法选取湖南中医药大学第一附属医院2016年3月 -2017年1月收治的脑外伤患者119例，随机分为对照组(n=38)、观察一组 (n=40)和观察二组(n=41)。对照组患者采用常规药物治疗，观察一组患者在 对照组基础上加用脑昔肌肽注射液，观察二组患者在对照组基础上加用单唾液 酸四己糖神经节背脂钠注射液。比较3组患者治疗前及治疗后1、3、7d血清神 经元特异性烯醇化酶(NSE)、格拉斯哥昏迷评分量表(GCS)评分，记录患者不 良反应发生情况。结果治疗前及治疗后1 d, 3组患者血清NSE水平、GCS评分 比较，差异无统计学意义(P0.05);治疗后3、7 d,观察一组、观察二组患者 血清NSE水平均低于对照组，GCS评分均高于对照组(P0. 05),但观察一组与 观察二组患者血清NSE水平、GCS评分比较，差异无统计学意义(P0. 05)。患 者均未出现严重药物不良反应。结论采用脑神经保护剂治疗脑外伤的临床疗效 明确，均可有效改善患者血清NSE水平及GCS评分，且安全性高。 关键词： 脑外伤;脑神经保护剂;治疗结果;安全性; 作者简介：张文佳，E-mail:li490481082@126. com 收稿日期：2017-07-12 Clinical effect and the safety of cranial nerve protective agent in treating craniocerebral trauma LI Li-bo ZHANG Wen-jia Hospital of Hunan University of Chinese Medicine; Abstract： Objective To discuss the clinical effect and the safety of cranial nerve protective agent in treating craniocerebral trauma. Methods A total of 119 cases of craniocerebral trauma patients were selected from March 2016 to January2017 in the First Affiliated Hospital of Hunan University of Chinese Medicine, which were randomly divided into control group ( n = 38) , the first observation group ( n 二 40) and the second observation group ( n 二 41) ? Control group was given conventional therapy, the first observation group was given naoganjitai injcction based on control group, the second observation group was given monosialotetrahexosylganglioside sodium injection. The serum neurone specific enolase ( NSE) and glasgow coma scale ( GCS) scores were compared among three groups before and after treatment of 1 d, 3 d, 7 d, and the adverse reactions were recorded. ResuIts Before and after treatment of 1 d, no significant diffcrcnccs of scrum NSE or GCS scores was found among the three groups ( P 0. 05) ; after treatment of 3 d, 7 d, the first observation group and the second observation group of serum NSE were lower than control group, GCS scores were higher than control group ( P 0. 0