含环糊精端基嵌段聚合物的合成及其自组装研究有机化学专业论文.docxVIP

湘潭大学 湘潭大学 2010 届硕士学位论文 II II Abstract Cyclodextrins have a hydrophobic cavity and hydrophilic interface. Due to this structure, cyclodextrins have ability to form inclusion complexes with numerous molecules. They are widely used in the fields of food, pharmaceutics and so on. The polymer which contains cyclodextrin is called cyclodextrin polymer (CDP). CDP not only have the abilities to inclusion, but also have well stability, solubility and adjustable character in chemical reaction. In this paper, β-cyclodextrin terminated of block polymers were synthesized and characterized. The self-assmebly behavior of these polymers was also studied. Contents and results of this dissertation are as following: First, the mono-6-O-Ts–β–CD was prepared by reacting β-cyclodextrin with tosyl chloride at 1:1 molar ratio in alkaline solution. The yield of mono-6-O-Ts–β–CD was promoted to 15% through changing the adding mode of tosyl chloride. Second, the mono-6-N3-β-CD was prepared. Finally, the production was characterized by FT-IR and 1H NMR. The β-cyclodextrin terminated block polymers (β-CD-PDMA-b-PNIPAM) were prepared by reacting mono-6-N3-β-CD with poly(N-isopropyla-crylamide)-b- poly(N,N-dimethylacrylamide) block copolymers (PDMA-b-PNIPAM) via click reaction. The products were characterized by FT-IR and 1H NMR. Moreover, thermo-induced micellization behavior of the β-CD-PDMA-b-PNIPAM and PDMA- b-PNIPAM in dilute aqueous solution was investigated by fluorescence, UV-Vis spectrometer and dynamic light scattering (DLS), from which we obtained the lower critical solution temperature (LCST), critical micelle concentration (CMC) and the particle size as well as the distribution. Keywords: cyclodextrin; thermoresponsive; block copolymer; “click” reaction; self-assembly PAGE PAGE IV 目 录 第 1 章 绪论 1 1.1 环糊精的性质及用途 1 1.2 含环糊精聚合物的合成 1 化学键合成 CDP 2 非共价键合成 CDP 6 1.3 含环糊精聚合物自组装研究现状 6 HYPERLINK \l _TOC_250000 1.4 “Click”反应特色及应用 7 1.5 本论文的研究内容、目的与意义 8 参考文献 9 第 2 章 单取代环糊精衍生物的合成 1