光动力治疗鲜红斑痣前后激光共聚集显微镜的观察分析-皮肤科专业论文.docxVIP

中文摘要： 中文摘要： 目的：本研究使用激光共聚焦显微镜对光动力治疗鲜红斑痣前后的疗效进行评 价。 方法：本研究共选取34位临床上确诊为鲜红斑痣的患者，给予两次光动力治疗。 第一次光动力治疗有约四分之一的患者为对照组，第二次光动力治疗不设对照 组。每位患者分别于每次治疗前，治疗即刻后，治疗四天后，治疗8周后行共聚 焦显微镜检查。 结果：未治疗的鲜红斑痣皮损处与同一患者正常皮肤比较，平均血管密度和平均 血管直径均较大，有统计学差异。对照组第一次治疗前与第一次治疗后8周比较， 平均血管密度和平均血管直径无统计学差异。治疗组第一次治疗前与第二次治疗 后8周比较，平均血管密度有统计学差异，平均血管直径无统计学差异。 结论：共聚焦显微镜是一种观察光动力治疗鲜红斑痣有效，无创的检测方法。 关键词：皮肤共聚焦显微镜鲜红斑痣光动力疗法 Abstract： Objective：the study utilizes the confocal microscope 1Io observe the efficacy of photodynamic therapy on port wine stain Methods：the 34 patients， clinically diagnosed with port wine stain by dermatologists，receive 2 photodynamic therapies．During first treatment． approximately one—fourth patients are assigned to the control group． There is no control group in the second treatment．All patients receive the confocal microscope examination before，immediately after，4 days after and 8 weeks after each treatment． Results：the mean vessel densi ty and diameter of port wine stain lesion is statistically more than those of normal skin．In control[group，there IS no statistical difference in terms of the mean vessel densitv and diameter of port wine stain between 8 weeks after and bef。ore the first treatment． In the treatment group，the mean vessel density decrease 3 significantly significantly 8 weeks after the second treatment，but no statistical difference in terms of the mean vessel diameter between 8 weeks after the second treatment and that before the first treatment WaS observed． Conclusion：the confocal microscope is an effective and non—invasive technlque to observe the efficacy of photodynami c therapy on port—wine stain KeDvord：confocal microscope port—wine stain photodynamic therapy 4 前言：1鲜红斑痣的概述： 前言： 1鲜红斑痣的概述： 鲜红斑痣(port wine stain)又称为葡萄酒样痣，是一种先天性的皮肤毛细血管 扩张，好发于面部，颈部及头皮等曝光部位。发病率为0．3％--2．1％1，对患者的 容貌及心理影响很大。大多数患者的发病年龄为1岁以内，成年后发病的情况少 见。鲜红斑痣的临床症状表现为单侧或者双侧的鲜红色斑片，压之可退色，压力 撤退时血液会再次充盈血管。随着患者年龄的增长，皮损颜色可变为紫红色，皮 损厚度可高于皮面，甚至可以在斑块基础上出现结节。不同性别之间鲜红斑痣的 发病率未见有明显统计学差异2。 2鲜红斑痣的治疗方法介绍： 1)激光： 目前而言，脉冲染料激光仍是治疗鲜红斑痣