聚苹果酸的微生物合成及应用研究进展-微生物学报.PDF

生 物 工 程 学 报 王媛媛 等/聚苹果酸的微生物合成及应用研究进展 1331 Chinese Journal of Biotechnology /cjbcn September 25, 2014, 30(9): 1331−1340 DOI: 10.13345/j.cjb.130632 ©2014 Chin J Biotech, All rights reserved 综 述 聚苹果酸的微生物合成及应用研究进展 王媛媛，全玉芬，宋存江 南开大学生命科学学院 分子微生物学与技术教育部重点实验室，天津 300071 王媛媛, 全玉芬, 宋存江. 聚苹果酸的微生物合成及应用研究进展. 生物工程学报, 2014, 30(9): 1331−1340. Wang YY, Quan YF, Song CJ. Progress in microbial synthesis and application of polymalic acid. Chin J Biotech, 2014, 30(9): 1331−1340. 摘 要: 聚苹果酸是一种优良的完全可生物降解的生物活性材料，在医学和药学领域有着极大的应用潜力。文 中结合我们的工作总结了近年来聚苹果酸代谢、聚苹果酸的微生物发酵合成以及聚苹果酸在医药领域的应用等 方面的研究进展，并对聚苹果酸的深入研究作了展望。 关键词: 聚苹果酸,微生物合成,生物活性材料 Progress in microbial synthesis and application of polymalic acid Yuanyuan Wang, Yufen Quan, and Cunjiang Song Key Laboratory of Molecular Microbiology and Technology for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China Abstract: Polymalic acid, known as a bioactive material, is completely biodegradable, and has far reaching application potential in medical field. Combined with our own findings, we summarized advances in polymalic acid metabolism, microbial fermentation synthesis, and application research in the medical field. Finally, prospect for further research was addressed. Received: December 12, 2013; Accepted: March 28, 2014 Supported by: National Basic Research Program of China (973 Program) (No. 2012CB725204), National High Technology Research and Development Program of China (863 Program) (No. 2012AA021505), National Natural Science Foundation of China (Nos. 311