载药纳米颗粒在微血管内靶向输运过程格子boltzmann模拟.PDF

中国工程热物理学会 传热传质学 学术会议论文 编号：143702 载药纳米颗粒在微血管内靶向输运过程 格子boltzmann 模拟 1 牛永健, 乐恺*, 张欣欣 (北京科技大学机械工程学院热能工程系 100083) (Tel Email:ustb_niu@163.com) 摘要：纳米颗粒作为药物输运的载体，其在微血管内的输运以及在血管壁的附着对药物输送的研究至 关重要。本文对载药纳米颗粒在微血管内的主动靶向输运过程进行了深入分析，在考虑流动阻力布朗 力以及颗粒与血管壁作用力等因素影响的基础上，建立了颗粒在微血管输运与分布的数学物理模型。 采用格子boltzmann 和格子气自动机方法模拟了血液流动和颗粒在微血管内的运动。对直径200nm 以 下的颗粒，忽略其所受的重力、浮力、范德华力和静电力的影响后，模拟结果表明，纳米颗粒悬浮液 的浓度越大、颗粒直径越小、血管直径越小以及血液粘度越小时，越多的颗粒附着在血管壁。计算结 果对纳米颗粒靶向输送药物的临床或实验研究有一定的参考价值。 关键词：格子boltzmann ；格子气自动机；纳米颗粒；靶向输运 The targeting transport of drug loaded nanoparticles in microvascular by lattice boltzmann method Abstract: Studying the transport and binding of nanoparticle in micro vessel has significant value on drug delivery system. We make a deep analysis on the targeting transport process of drug loaded nanoparticles in micro vessel, and establish the mathematical physical model of particle transport and distribution in consideration of the effect of flow resistance, brown force and particle adhesion. We simulate the blood flow and particle motion in micro vessel by lattice boltzmann and lattice gas automata method. It is ignored that the effect of gravity, buoyancy, van der waals force and electrostatic force of nanoparticle which the diameter is under 200nm. The simulation results show that more nanoparticles will attach to the vessel wall with larger concentration of nanoparticle suspension, smaller particle diameter, smaller vessel diameter and smaller blood viscosity. We hope the results have a certain reference value for clinical or experimental study on targeting system of drug loaded nanoparticle. Key words: lattice boltzmann method; latti