阿尔茨海默病与雌激素和褪黑素的相关性研究进展Correlationof.PDF

2376 现代生物医学进展 ProgressinModernBiomedicine Vol.11 NO.12 JUN.2011 · · 阿尔茨海默病与雌激素和褪黑素的相关性研究进展 1,2 1△ 1 熊元元 李有秋 彭耀金 ( 1 湖南师范大学医学院人体解剖学教研室 湖南长沙410006; 2 中南大学湘雅医院神经外科湖南长沙410006) AD 摘要：阿尔茨海默病（ ）是引起痴呆的第一病因，其发病机制尚不十分明确。 目前尚无特效的药物可逆转脑功能缺损或阻止病 E 情进展，临床上用胆碱乙酰转移酶抑制剂、抗精神症状药物、维生素 等均只能轻微改善症状。雌激素和褪黑素在基础和临床研 AD AD 究中都显示对 有治疗作用，且二者的疗效与 的病程有明显相关性。 ; ; 关键词: 阿尔茨海默病雌激素褪黑素 R74 A 1673-6273 2011 12-2376-05 中图分类号： 文献标识码： 文章编号： （ ） Correlation of Alzheimers Disease to Estrogen and Melatonin 1,2 1△ 1 XIONG Yuan -yuan , LI You -qiu , PENG Yao-j in ( 1 The human anotomy dep artment, Medical School of Hunan namol college,Hunan, Changsha, 4 10006,China; 2 Xiangya hosp ital of Central South University, Hunan, Changsha, 4 10006,China) ABSTRACT: Alzheimers disease is the top etiology of dementia,whose pathogenesis is not clear yet.So far ,there is no effective drugs to reverse the defect in brain function or prevent its progression.Drugs used in clinical practice nowadays such as the choline acetyltransferase inhibitor,anti-psychotic symptoms of drugs, vitamin E can do only modest improvement in symptoms. Melatomin and estrogen are proved to be useful for AD both in basic and clinical studies and their efficacy both related to the duration of AD.In this paper, estrogen and melatonin for the treatment of AD are reviewed. Key word: Alzheimers disease Estrogen Melatomin ； ； Chinese Library Classification(CLC): R