水化对冠状动脉造影患者造影剂肾病的影响-中国动脉硬化杂志.PDF

840 ISSN 1007鄄3949 Chin J Arterioscler,Vol20,No9,2012 ·临床研究 · [文章编号]摇 1007鄄3949(2012)20鄄09鄄0840鄄03 水化对冠状动脉造影患者造影剂肾病的影响 刘天华,戚保桥,史 骏,刘新兵,黄红漫,冯六六,周明成 (上海市市东医院心内科,上海市200438) [关键词]摇 冠状动脉造影;摇 造影剂肾病;摇 水化 [摘摇 要]摇 目的摇 观察水化对冠状动脉造影患者肾功能的影响及造影剂肾病的发生率。 方法摇 应用低渗非离子 型造影剂碘海醇进行冠状动脉造影,将216例行冠状动脉造影或冠状动脉介入治疗患者随机分为两组:水化组112 例,在常规补液基础上进行水化治疗;对照组104例,常规补液治疗,比较两组在造影前及造影后48 h、1周时血清 肌酐、尿茁2微球蛋白的浓度变化,观察两组造影剂肾病的发生率。 结果摇 水化组和对照组在造影后48 h血清肌 酐、尿茁2微球蛋白均升高,以对照组升高更显著。 造影后1周两组均下降。 水化组造影剂肾病发生率为4%,对照 组为17%。 结论摇 加强水化能减轻肾功能伤害,减少造影剂肾病的发生率。 [中图分类号]摇 R5 [文献标识码]摇 A Study on Hydration in Prevention of Contrast鄄Induced Nephropathy After Coronary Angiography LIUTian鄄Hua,QI Bao鄄Qiao,SHIJun,LIU Xin鄄Bing,HUANG Hong鄄Man,FENG Liu鄄Liu,and ZHOU Ming鄄Chen (Department of Cardiology,Shidong Hospital of Shanghai,Shanghai200438,China) [KEY WORDS]摇 Coronary Angiography;摇 Contrast鄄Induced Nephropathy;摇 Hydration [ABSTRACT]摇 摇 Aim摇 To observe the effects of hydration on renal function and the incidence of contrast鄄induced ne鄄 phropathy in patients undergoing coronary angiography.摇 摇 Methods摇 The low osmolar and nonionic contrast media (io鄄 hexol)wasusedinallpatients.摇 Atotalof216 patients,whowouldundergocoronary angiographorpercutaneouscoronary interventional theraphy were enrolled into the study.摇 They were randomly divided into two groups:the hydration group (n=112)andthecontrol group (n=104).摇 Thetreatedgroupreceivedhydrationtheraphy aswell asgeneral intravenous fluid infusion.摇 The control group only received general intravenousfluid infusion.摇 The levels of serum creatinine (Scr) andurine 茁2鄄microglobulin (茁2MG)weremeasuredbeforeangiography and48hours,oneweekaftercoronary angiograpy. 摇 The incidence of co