磷脂胆碱聚乳酸自组装胶束的结构与性能-中南大学学报.PDF

40 6 () Vol.40 No.6 2009 12 Journal of Central South University (Science and Technology) Dec. 2009 1 1, 2 2 1, 3 (1. 610065 2. 5247 34060 3. 610065) (Phosphorylcholine-containing poly(L-lactide), PLLA-PC) (Critical micelle concentration, CMC)23 mg/L 0.9%CMC 37 15 h PLLA-PC TQ423.3 R318.08 A 1672−7207(2009)06−1552−05 Structure and stability of micelles formed by self-assembling of biodegradable phosphorylcholine-containing poly(L-lactide) 1 1, 2 2 1, 3 QIU Zhi , CHEN Yuan-wei , LI Su-ming , LUO Xiang-lin (1. School of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China; 2. CNRS 5247, University Montpellier I, Montpellier 34060, France; 3. National Key Lab of Polymer, Sichuan University, Chengdu 610065, China) Abstract: Self-assembled micelles were prepared from phosphorylcholine-containing poly (L-lactide)(PLLA-PC) with similar molecular structure and molecular mass to natural phospholipids. The global structure with hydrophilic shell and hydrophobic core is confirmed by transmission electron microscope (TEM) and confocal laser scanning microscope (CLSM). The results show that critical micelle concentration (CMC) is detected to be 23 mg/L with surface tension method, which is much lower than that of natural p