GN%2f双药含铂%2f单药方案一线治疗老年晚期NSCLC的-研究.pdfVIP

摘要 2 （X=4.884,P=0.027），GN组与单药组的毒性反应发生率相似，差异无统计学意 2 X =0.453,P=0.501 义（ ）。双药含铂组在胃肠道反应及肾功能损害方面较另外两组 发生率更高。 结论： 1、双药含铂方案较非含铂方案副反应大，尤在肾毒性及胃肠反应方面明显。 2、吉西他滨联合长春瑞滨一线治疗老年晚期NSCLC 患者疗效肯定，与含 铂两药方案接近，大部分患者肿瘤相关症状可有效缓解，疾病控制满意，且毒 性反应可耐受。 3 ECOG 、 评分差、高龄、肾功能差等不宜行双药含方案化疗的患者可优先 考虑非含铂的吉西他滨联合长春瑞滨方案。 关键词：非小细胞肺癌；老年人；一线治疗；非含铂方案；生存时间；logistic 回归；Cox多因素分析 III 万方数据 Abstract ABSTRACT Background: Worldwide,with the increasin morbidity andmortality ofelderlypatients with NSCLC, the elderlypatients with NSCLC gradually become a common concern on the cancer community. In the past, many elderly patients with advanced non-small celllun cancerwithouttreatment,becausethinktreatmenttoxicitymayoutweighthe benefitsofit.However,itisclearthatpatientwithtreatmentmightbeofbenefitnow. Some meta-analysis pointed out that chemotherapy compared to best supportive [1] treatment,survivalhasaslightincreasein ,sincethatchemotherapyhasbecomethe firsttreatment of advancedNSCLC. However, elderlypatients because of declinein physiological function and complications, tolerance to chemotherapy is poor, and theyalwaysdotheclinicalstudyisless,manyclinicalstudiesexcludeelderlypatients, theresults also cannotbe extrapolatedto elderlypatients, sofarthere isno standard solutions for the treatment of elderly NSCLC. In recent years, studies of elderly NSCLC treatment is becomin more and more attention. Therefore, correct understandin oftheroleofchemotherapysurvivaladvant