神经系统药理—吴希美(解热镇痛药课件.pptVIP

Chapter 27Antipyretic-Analgesic and Antiinflammatory Drugs;A. General Pharmacological properties;;;2. Antipyretic effects Inhibition of PGE2 production in the hypothalamus induced by endogenous pyregens after pathological stimuli ? temperature ? notes: symptomatic control only, not be indicated in all patients with fever. The effect on body temperature is different from that of chlorpromazine.;Comparison of properties of two types of drugs;3. Analgesic effects Analgesic effect is resulted from inhibition of PGE2 production. Effective on the pain of low to moderate intensity related