Tim Aitmant.aitman@csc.mrc.ac.uk课件.ppt

Current Gene Identification Projects Salt-sensitive hypertension in SHR Pulmonary hypertension in F344 rats Nephrotoxic nephritis in WKY rat 精品文档 1% salt solution for drinking 1% salt solution for drinking 100 110 120 130 140 150 80 90 100 110 120 (days of age) mm Hg (days of age) 150 160 170 180 190 90 100 110 120 80 mm Hg Night-time, diastolic 160 100 110 120 130 140 150 80 90 100 110 120 (days of age) 1% salt solution for drinking mm Hg 150 160 170 180 190 200 210 80 mm Hg 90 100 110 120 (days of age) 1% salt solution for drinking Night-time, systolic Day-time, systolic Day-time, diastolic SHR SHR.18 24 Hour Blood Pressure Measured by Telemetry in SHR and SHR.18 Congenic Strain SHR SHR.18 SHR SHR.18 SHR SHR.18 精品文档 D18Rat32 Ttr D18Rat12 Adrb 10cM * ? Human BP QTL (Krushkal et al, 1999) Mouse BP QTL (Wright et al, 1999) * ? Garrett et al 1998, Dahl S/Lew Jacob et al 1991, SHRSP/WKY Cowley et al 2000, BN/Dahl S Kovacs et al 1997, SHR/BBOK Previously Mapped Rat BP QTLs (95% C.l.) SHR.18 Congenic interval Rat Chr. 18 Differentially Expressed Genes and BP QTLs on Rat Chromsome 18 精品文档 D18Rat32 DE4 Ttr D18Rat12 Adrb DE1 DE2 DE3 Genetic Markers Differentially expressed genes 10cM * ? Human BP QTL (Krushkal et al, 1999) Mouse BP QTL (Wright et al, 1999) * ? Garrett et al 1998, Dahl S/Lew Jacob et al 1991, SHRSP/WKY Cowley et al 2000, BN/Dahl S Kovacs et al 1997, SHR/BBOK Previously Mapped Rat BP QTLs (95% C.l.) SHR.18 Congenic interval Rat Chr. 18 Differentially Expressed Genes and BP QTLs on Rat Chromsome 18 精品文档 D18Rat32 DE4 Ttr D18Rat12 Adrb DE1 DE2 DE3 Genetic Markers Differentially expressed genes 10cM * ? Human BP QTL (Krushkal et al, 1999) Mouse BP QTL (Wright et al, 1999) * ? Garrett et al 1998, Dahl S/Lew Jacob et al 1991, SHRSP/WKY Cowley et al 2000, BN/Dahl S Kovacs et al 1997, SHR/BBOK Previously Mapped Rat BP QTLs (95% C.l.) SHR.18 Congenic interval Rat Chr. 18 Differentially Expressed Genes and BP QTLs on Rat Chromsome 18 28 bp insertion iden