2018NACI建议：麻疹暴露后预防（更新版）.pdf

RAPID COMMUNICATION Updated NACI recommendations for measles post-exposure prophylaxis 1 2 3 1 MC Tunis , MI Salvadori , V Dubey , O Baclic on behalf of the National Advisory Committee on Immunization (NACI)* Affliations Abstract 1 Public Health Agency of Canada, Centre for Immunization and Background: Human immune globulin (Ig) products are currently recommended as post-exposure Respiratory Infectious Diseases, prophylaxis (PEP) for measles in certain susceptible groups. However, successful measles Ottawa, ON vaccination programs in North America have led to low circulation of measles virus and most 2 blood donors now have vaccine-derived immunity. Concurrently, the concentrations of anti- NACI Measles, Mumps, Rubella, measles antibodies in human Ig products have shown trends of gradual decline and previously Varicella Working Group Chair, London, ON recommended doses and routes of administration may no longer be optimally protective. 3 NACI Measles, Mumps, Rubella, Objectives: To review the literature and update recommendations on post-exposure prophylaxis Varicella Working Group Vice for measles, including dosing and route of administration, for measles Ig PEP in suscept