丙酮醛抗肿瘤机制的研究进展.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(4): 449–454 DOI: 10.11844/cj cb.2016.04.0296 丙酮醛抗肿瘤机制的研究进展 * * 何甜甜 李春梅 李晨丽 陈 圆 孟庆贺 吕建新 (温州医科大学检验医学院、生命科学学院, 浙江省医学遗传学重点实验室, 温州325035) 摘要 丙酮醛作为正常的生理代谢产物, 可来源于多条代谢通路, 最主要的来源是糖酵解途 径, 丙酮醛分解主要是在乙二醛酶系统的作用下最终转化为D-乳酸。丙酮醛具有高度的活性和细 胞毒性, 它在多种类型的肿瘤组织中含量较低。丙酮醛能够抑制恶性肿瘤细胞的增殖、诱导其凋亡、 抑制肿瘤的转移, 并能通过增强机体的免疫力以及提高对现有抗肿瘤药物的敏感性等作用更进一 步地发挥抗肿瘤效应。深入研究其抗肿瘤机制能够为临床试验提供依据、使其成为有潜力的新型 抗肿瘤药, 该文就丙酮醛可能的作用机制予以综述。 关键词 丙酮醛; 抗肿瘤; 机制 Advance on the Anti-tumor Mechanism of Methylglyoxal He Tiantian, Li Chunmei, Li Chenli, Chen Yuan, Meng Qinghe*, Lü Jianxin* (Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China) Abstract As a normal physiological metabolites, methylglyoxal (MG) is formed from various metabolic routes, among them glycolytic pathway provides the most important source. MG is mainly catalyzed by glyoxalasesystem, it converts to D-lactate finally. MG is highly reactive and it processes cell toxicity. MG is lower in many types of cancers. The anticancer effect of MG is due to its anti-proliferative properties, the abilities of inducing apoptosis and inhibiting tumor metastasis, it can also enhance immune system and increase sensitivity to antitumor agents. Further investigation of the mechanisms will provide evidences for next stage clinical research and make this compound to be a potential therapeutic agent, the aim of this review is to summarize the mechanisms of MG′s antitumor effect. Keywords methylglyoxal; anti-tumor; mechanism 丙酮醛是人体内正常的代谢产物, 可由碳水化 过程及其抗肿瘤作用机制的研究进展综述如下。 合物、脂质及蛋白质代谢产生, 正常生理情况下它