氧化石墨烯固化挥发油的研究Solidificationofvolatileoil.pdf

222 药学学报 Acta Pharmaceutica Sinica 20 15, 50 (2): 222 226 化石墨烯固化挥发油的研究 1, 2 1, 2* 1* 1 2 严红梅 , 贾晓斌 , 张振海 , 孙 娥 , 徐怡皓 (1. 江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏 南京 2 10028; 2. 南京中医药大学, 江苏 南京 2 10046) 摘要: 本文考察了氧化石墨烯 (graphene oxide, GO) 固化挥发油的特性。分别应用GO 吸附丁香油与莪术油, 以丁香酚和莪术醇收率为指标, 优选GO 用量; 采用差示扫描量热法和扫描电镜法对固化粉末进行物相表征; 考 察GO 对挥发油中有效成分体外溶出和受热稳定性的影 。结果表明, GO 与挥发油最佳固化比例为1 ∶1, 挥发 油被固化后, 对有效成分的体外溶出速率基本无影 , 且受热稳定性得到提高。GO 固化中药挥发油具有一定的 应用前景, 值得进一步研究。 关键词: 挥发油; 氧化石墨烯; 吸附率; 表征; 体外溶出度; 受热稳定性 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 15) 02-0222-05 Solidification of volatile oil with graphene oxide 1, 2 1, 2* 1* 1 2 YAN Hong-mei , JIA Xiao-bin , ZHANG Zhen-hai , SUN E , XU Yi-hao (1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Ac ademy of Chinese Medicine, Nanjing 210028, China; 2. Nanji ng University of Chinese Medicine, Nanj ing 210046, China ) Abstract : To evaluate the properties of solidifying volatile oil with graphene oxide, clove oil and zedoary turmeric oil were solidified by graphene oxide. The amount of graphene oxide was optimized with the eugenol yield and curcumol yield as criteria. Curing powder was characterized by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The effects of graphene oxide on dissolution in vitro and th