生长因子受体结合蛋白2Grb2的生理功能.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(7): 1029–1035 DOI: 10.11844/cjcb.2015.07.0061 生长因子受体结合蛋白2(Grb2) 的生理功能 张新宇 安 输 郭晓汐 刘 莹 杨 洋 徐天瑞* ( 昆明理工大学生命科学与技术学院细胞信号传导实验室, 昆明 650500) 摘要 生长因子受体结合蛋白2(growth factor receptor bound protein 2, Grb2)是一种在细胞中 广泛表达的衔接蛋白。作为信号通路上的节点蛋白, Grb2在细胞内许多信号传导通路中起着重要 报 调控作用。Grb2的异常表达或活化与肿瘤的发生息息相关。大量研究表明, 它可以作为抗肿瘤治 疗的分子靶点, 因此Grb2抑制剂也就成了抗肿瘤药物研发的一个热点。该文对Grb2的生理功能和 抑制剂研究的最新进展进行了综述。 关键词 生长因子受体结合蛋白2(Grb2); 受体酪氨酸激酶; 肿瘤治疗; 选择性抑制剂 学 Physiological Function of Growth Factor Receptor Bound Protein 2 (Grb2) 学 Zhang Xinyu, An Shu, Guo Xiaoxi, Liu Ying, Yang Yang, Xu Tianrui* (Cell Signaling Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China) Abstract Growth factor receptor bound protein 2 (Grb2) is a ubiquitously expressed adaptor that is 物 essential for a variety of cellular signal transduction pathways and acts as critical downstream intermediary in several oncogenic signaling pathways. The overexpression or aberrant activation of Grb2 is closely related to tumorigenesis. The broad involvement of Grb2 in multisteps of the tumorigenesis makes it an excellent target for antitumor therapy, and plenty of studies have shown that Grb2 molecules can be successfully targeted for anti- 生 metastatic therapeutics. Therefore, many Grb2 antagonists have been developed and they show strong antitumor activities. In this article, we summarized the research progress on physiological function of Grb2 and its inhibitors. Keywords growth factor receptor bound protein 2 (Grb2); RTK; tumour therapy; selecti