慢性阻塞性肺疾病与继发骨质疏松症的相关性研究-中医内科学专业毕业论文.docxVIP

Y Y lD07563 中文摘要 本文回顾了近十年来中医对骨质疏松症(osteoporosis，OP)认识的研究以及近 几年慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)与骨质疏松 症的相关性研究。文章从中西医两个方面阐述了对COPD与继发骨质疏松症的 认识，认为COPD是OP发生的危险因素之一，发病机理可能与吸烟、缺氧、内 分泌紊乱、营养不彘以及激素治疗等相关。西医治疗认为钙剂、维生素D和骨 吸收抑制剂三药联用效果较好，骨形成药物有待于进一步临床检验。传统中医认 为本病属于“骨痿”、“骨痹”等范畴，与肾中精气盛衰有关，并涉及肝、脾二脏。 本文认为肺失治节也是肾精亏虚的重要因素，并着重讨论了肺肾为病的相关病 机，认为COPD及OP在中医理论方面有共同的发病机理。本文还简要介绍了现 代医学对“肾虚”的认识，以及中医治疗OP的作用及可能的机制。通常认为 OP的发生是多种因素共同作用的结果，而中医治疗是以整体观为主，表现为多 层次、多环节、多途径、多靶点的调节作用，是任何单～化学药品无法比拟的。 故中医药治疗OP有广阔的前景。目前应积极利用现代科技手段，发挥中医特色 和中西医结合优势，为人类健康事业作出更大的贡献。 关键词： 骨质疏松症慢性阻塞性肺疾病相关性发病机制治疗 ABSTRACTThis ABSTRACT This is a reviewed study of the Traditional Chinese Medicine(TCM)researches on osteoporosis(OP)in the last decade，and combined with a relativity study of chronic obstructive pulmonary disease(COPD)and OP in recent years This study explains what is secondary osteoporosis caused by COPD in both ways of TCM and Modem medicine，and shows that COPD is one of the risk factors lead to OP,which pathogenesis possibly was related to smoking，hypoxia，endocrine disturbance， dystrophy and hormonal therapy，et a1．The Modem medicine believed that combined drugs treatment(calcium，vitamin D and osteo—absorption inhibitors)for OP will be a beRer choice than others．Also the new drugs for bone formation are still in lab stages which need pass clinic test．In TCM this disease is belong to“bone flaccidility Zheng’’or‘‘bone Bi Zheng”，and mostly depend on the state of kidney—essence whether are wax or wan，also closely related to the function of spleen and liveL This study shows that the function of lung maladjustment is one of key risk factors of deficiency of kidney—essence，and forther discusses the correlation pathogenesis between lung and kidney，also believes that COPD and OP have a common pathogenesis based on the theory of TCM．In this article，the concept of“Kidney deficiency”based on Modem medicine and the potential mechanism of’FCM therapy for OP are briefly introduced．In general the pathogenesis of OP is