溴化法与氯化法合成杀菌剂甲环唑.pdfVIP

南京农业大学学报 　2001 , 24 (3) : 97～100 　 Journal of Nanjing Agricultural University 溴化法与氯化法合成杀菌剂甲环唑 杨春龙 　蒋木庚 　王鸣华 (南京农业大学理学院 , 南京 210095) ( ) 摘要 : 以 1 , 2丙二醇、间二氯苯、1H1 , 2 , 4三氮唑等为原料 , 分别用溴化法与氯化法对 1 [2 2 , 4二氯苯基 4 ( ) 甲基1 ,3二氧戊环2基] 甲基1H1 , 2 , 4三氮唑 以下称甲环唑 的合成进行了研究。合成产物得到核磁共振与气相 色谱/ 质谱确认。溴化法总收率 632 % , 产物纯度可达 84 %以上。氯化法总收率369 % , 产物纯度 60 %左右。对关键步 骤中的反应时间与温度对产物质量及收率的影响进行了比较与分析 ,并就甲环唑预防白粉病菌侵染黄瓜进行了初步试验。 关键词 : 杀菌剂 ; 甲环唑; 溴化 ; 氯化 ; 合成 中图分类号: TQ45547 　　　文献标识码 : A 　　　文章编号 : (2001) Synthesis of fungicide 1[ 2( 2 ,4dichlorophenyl) 4methyl 1 ,3dioxolan2yl] 1 H1 ,2 ,4triazole by routes of bromination and chlorination Yang Chunlong , Jiang Mugeng and Wang Minghua (College of Science , Nanjing Agric Univ , Nanjing 210095 , China) ( ) Abstract : The synthesis of fungicide 1 [2 2 ,4dichlorophenyl 4methyl1 ,3dioxolan2yl ]1H1 ,2 ,4triazole were studied with the starting materials of 1 ,3dichlorobenzene ,1 ,3propyleneglycol ,1H1 ,2 ,4triazole etc. by the routes of bromination and chlorination. The title compounds were confirmed by 1H NMR and GCMS. 632 % total yield and more than 84 % product purity were obtained by bromina tion route , 369 % and around 60 % respectively by chlorination route. The effects of reaction time and temperature of key steps on the yield and product quality were compared and discussed emphatically. The preliminary experiment showed t