慢性阻塞性肺病与晚期肺癌气虚证对血管内皮细胞功能的影响-中医诊断学专业毕业论文.docxVIP

皮细胞功能改善，病情好转。 皮细胞功能改善，病情好转。 (2)慢性阻塞性肺病、肺癌晚期肺气虚证患者治疗前与正常对照组比较，t—PA 含量均降低(均户}O．05)，但肺癌患者t_PA含量降低更明显(户《O。001)；PAI—l含 量两组均较正常组明显升高，慢阻肺组差异有显著性(户!O．05)，晚期肺癌组差异则 无显著性(户》O．05)；vWF含量两组均较正常组上升，但肺癌比慢阻肺组上升更明显， 差异均有显著性(Ko．05)；NO含量两组均升高，慢阻肺组上升更明显，但差异均无 显著性(尸O．05)。结果表明，慢阻肺、晚期肺癌肺气虚证患者血管内皮细胞功能均 受损，微循环血管的舒缩功能减退、血小板呈高粘附与高聚集、凝血与纤溶系统的活 性降低，而肺癌患者较慢阻肺患者功能受损更严重，但差异无显著性，可能是因肺癌 患者纳入病例过少所致。 三、结论：慢性肺病肺气虚证患者血管内皮细胞功能减退，血液处于高凝状态，与 中医气不行血的理论相一致。这与中医肺赣百脉的理论十分接近，可丰富中医基础理 论研究的内容，促进中医理论研究的深入。本研究指标有可能成为解释中医“肺朝百 脉”最接近的现代实验研究指标以及对慢性肺系疾病临床治疗效果的客观评价指标： 关键词：肺朝百脉／中医病机；肺气虚证，病因病机：气虚血瘀；NO／nfil液；vWF／ 血液；t-PA／IdL液；PAI-1／血液；血管内皮细且包／损伤 l l mpact of 0 i Def i cency Syndrome of COPD and Late Lung Cancer on the Vascular EndotheI．aI Cel|’s Functlon Special ity：TCM DioIoge Author：Chen CaiYing(Student Affai r Office) Tutor：Prof．Chen Oun ^bstract Since there is close relationship between lung and blood vessels，the mechanism of the“lung faces the hundred vessels”can be further explained through deep study on that relationship．This task selected patients with qi deficiency syndrome of such chronic pulmonary diseases as COPD and late lung cancer to be studied．The NO,vWF(von willebrand factor)，t—PAJ PAI—l and t=PA／ PAI—1 were chosen to be the examine indexes。By observing the impact of qi deficiency syndrome of COPD and late lung cancer on the vascular endothelial cell function，the relationship between lung and blood vessels was explored and discussed，and thus，to provide the closest modern research indexes for the explanation of the TCM theory of “lung faces the hundred vessels”and the objective indexes evaluating the treatment effect of the chronic lung disease． I Literature studies on qi deficiency syndrome of COPD and late lung cancer This study reviews the recognitions in ancient TCM literatures about the theory of“1ung faces the hundred vessels”，diseases such as cough，asthma， lung distension and lung accumulation。and the relationship between those diseases and lung qi deficency syndrome．It’S considered as follows：the