抗磷脂综合征12例临床分析-内科学(风湿病学)专业毕业论文.docxVIP

浙江大学硕士学位论文The 浙江大学硕士学位论文 The clinical analysis of patients with antiphospholipid syndrome disease：a report of 12 cases Yanling Wang，Huaxiang Wu Department ofRheumatology,Second Affiliated Hospital，Colledge of Medicme，Zhejiang University,Hangzhou 3 1 0009，China 0bjective To investigate the clinical manifestations．1aboratory examination and treatment of antiphospholipid synom《AP∞． Methods 12 patients witll defined APS admitted from 2002 to 2007 were analyzed Results 12 patients were analyzed．Women were affected 5 times as that ofmen． 3 patients with primary APS and 9 patients with secondary APS．The patients witll secondry APS weTe mainly complicated wi也autoimmune diseases．including 6 cases of systemic lupus erythernatosus．Vascular thrombosis w粕presented in around 66．7％of the patients in this study．Thrombosis fiequenfly involved the lower limb deep VenOUS system(7 cases 41．1％)，upper limbs venous system(4 cases 23．5％)，neural system(3 ca∞s 17．6％)，and the abnormal pregancy rate in the 8 married women was 62．5％． Platelet defect Was in 83．3％of the patien忸．The prevalence of antiphospholipid antibody(aCn wasl00％． Conclusion APS Occll_rS most commonly among yong womffn,which is a disorder chrac蜘zed by recurrent venous or medal thrombosis and／or fetal losses associated with positive aCL．Thrombosis frequently OCCURS in deep VenO璐system、 3 浙扛大学硕士学位论文c圮rebral 浙扛大学硕士学位论文 c圮rebral vascular system．Antiplatelct willl low《losege aspirin and long-term Key words antiphospholipid syndrome；antiphospholipid antibody；thrombosis； 4 浙江大学硕士学位论文抗磷脂综合征12例临床分析 浙江大学硕士学位论文 抗磷脂综合征12例临床分析 浙江大学医学院 内科学(风湿病学) 硕士研究生 王艳玲 导 师 吴华香 抗磷脂综合征(autiphospholipid syndrome，APs)属自身免疫性疾病，又叫 抗心磷脂抗体综合征、狼疮抗凝物综合征以及休氏综合征(Hughes’syndrome)。 是指由抗磷脂抗体(antiphospholipid antibody，aPL抗体)引起的一组临床征象的总 称，主要表现为血栓形成、反复流产、血小板减少等。它可以单独出现，称为原 发性抗磷脂综合征；或者伴随其他疾病而出现，称为继发性抗磷脂综合征。原发 性APS和继发APS的主要临床特点相似，但后者同时具有原发病的相应表现。本 研究拟通过对确诊的APS病例的临床特点、实验室检查和治疗进行分析总结，以 提高对本病的认识。为了加强对该病的认识，本文对我院近年来收治的12例APS 患者的临床资料进行了回顾性分析。 1．对象与方法 1．1病例资料回顾性分析自2002-2007年在浙江