慢性阻塞性肺疾病稳定期γ-干扰素和基质金属蛋白酶-9与肺功能相关性的分析-内科学(呼吸系病)专业毕业论文.docxVIP

万方数据 万方数据 反映 COPD 严重程度及其预后的指标。且随着 COPD 稳定期患者肺功能的降低， 患者血清中 IFN-γ、MMP-9 浓度均升高，且 IFN-γ、MMP-9 浓度呈正相关，说明 IFN-γ、MMP-9 均参与了 COPD 稳定期的慢性炎症反应，引起气道、肺实质、肺 血管组织重塑，造成了肺功能的损伤。 【关键词】慢性阻塞性肺疾病；基质金属蛋白酶-9；γ-干扰素；肺功能 III The research of the relationship between IFN-γ and MMP-9 together with pulmonary function in stable COPD Major:respiratory medicine Postgraduate: Tan Chunjiang Supervisor: Du Juan Gao Qi [Abstract] Objective: It is properly less that the research which is used to evaluate the relevance between the concentration of MMP-9 and IFN-γ in serum together with the patients’ pulmonary function in stable Chronic obstructive pulmonary disease at present, our research is developed to investigate the relevance between the concentration of MMP-9 and IFN-γ in serum together with the patients’ pulmonary function in stable Chronic obstructive pulmonary disease (COPD). Methods: According to the “diagnosis and treatment guidelines of chronic obstructive pulmonary disease 2013”, eighty patients with stable chronic obstructive pulmonary disease were divided into 4 groups as group I, group II, group III and group IV, and twenty-five healthy people were serviced as control group, which accords to forced expiratory volume in one second prediction percentage/force vital capacity(FEV1/FVC%)and forced expiratory volume in one second prediction percentage(FEV1%pred)in the guidelines. We prepare analyze the relevance between concentration of IFN-γ and MMP-9 in serum and the pulmonary function after using some special statistics methods and comparing the levels of FEV1%pred and FEV1/FVC of each group and testing the concentration of IFN-γ and MMP-9 levels of them. Results : The difference between gender and age of stable COPD patients and healthy volunteers was not statistically significant(P＞0.05). In stable COPD, with the decrease of pulmonary function, the forced expiratory volume in one second prediction percentage/force vital capacity(FEV1/FVC%)and forced expiratory volume in one seco