长沙市疑似预防接种异常反应监测分析与评价.docVIP

长沙市疑似预防接种异常反应监测分析与评价 林希建 胡强(长沙市疾病预防控制中心 410001) 【摘要】目的 分析长沙市疑似预防接种异常反应(Adverse Events Following Immunization, AEFI)发牛特征，评价AEFI监测系统运转状况、疫苗的安全性和预 防接种服务质量。方法通过疾病监测信息管理系统收集全市2008?2012年报告 的AEFI个案数据，釆用描述性方法对相关指标进行流行病学分析。结果长沙市 2008?2012年报告AEFI个案828例，一般反应691例(83.45%),偶合症74例 (8.94%),异常反应62例(7.49%),心因性反应1例(0.12%)； 0?1岁儿童发 牛的反应占报告总数的71.50%；接种后24小时内发牛的反应占89.01%；反应发 牛的疫苗按报告数排名前五的是百白破疫苗发生率(118.61/100万剂次)、含麻 疹类疫苗(93.52/100万剂次)、A群流脑疫苗(107.55/100万剂次)、乙脑减毒 活疫苗(90.57/100万剂次)、乙肝疫苗(30.21/100万剂次)；临床损害表现以发 热、硬结(或红肿)、过敏性反应最为多见。结论长沙市监测系统运转正常，疫 苗的安全性和预防接种服务质量良好，全市AEFI的发生在预期范围内。 【关键词】疑似预防接种异常反应疫苗发牛率监测 【中图分类号】R18 【文献标识码】A 【文章编号】2095-1752 (2013) 32-0135-02 Subject Analysis and assessment on surveillance system of adverse events following immunization in Chansha Authors LIN Xijian, HU Qiang ( Department of Immunization Program, Changsha Center for Disease Prevention and Control, 410001, China) [Abstract】 Objective To study the situation of adverse events following immunization ( AEFI) in Changsha from 2008 to 2012 and to evaluate the system operation condition, vaccine safety and the quality of immunization services. Methods The data of AEFI in Changsha during 2008 -2012 was input into Excel or SPSS by using descriptive method to epidemiological analysis. Results 828 cases were reported in Changsha during 2008 -2012, The general reaction was 691(83.45%),Coupling was 74(8.94%)and abnormal reaction was 62(7.49%).Vaccine reactions were often occurred within Id after vaccination, Cases le; 1 year old accounted for 71.50%. DTP vaccine reaction incidenee rate was 118.61 per 100,000 doses,MV vaccine reaction incidenee rate was 93.52 per 100,000 doses, MenA vaccine reaction incidenee rate was 107.55 per 100,000 doses, JE-I vaccine reaction incidenee rate was 90.57 per 100,000 doses, HepB vaccine reaction incidenee rate was 30.21 per 100,000 doses. Conclusions The system had been operated efficiently,the safety of the vaccine and vaccination services were good,the reported incidenee rates of AEFI in chan