天津医科大学内科学课件 Intestinal Tuberculosis.pptVIP

* * * * * * * * * * * 还有1、生理因素 2、解剖因素 入侵的结核杆菌数量多机体免疫力下降、肠壁局部抵抗力减弱而、毒力强时才会发病。 * Definition: Macroscopical cheesy necrosis seen in tuberculosis. Granular tissular necrosis microscopically seen in tuberculoid granuloma. [eks?kri:t?] * * * * Some people develop active TB disease soon after becoming infected, before their immune system can fight off the bacteria. Other people may get sick later, when their immune system becomes weak for another reason. Babies and young children often have weak immune systems. People infected with HIV, the virus that causes AIDS, have very weak immune systems. Other people can have weak immune systems, too, especially people with any of these conditions: substance abuse; diabetes mellitus; silicosis; cancer of the head or neck; leukemia or Hodgkins disease; severe kidney disease; low body weight; certain medical treatments (such as corticosteroid treatment or organ transplants); specialized treatment for rheumatoid arthritis, or Crohns disease * is designed to build public awareness about the global epidemic of tuberculosis and efforts to eliminate the disease. Today tuberculosis causes the deaths of about 1.7 million people each year, mostly in the Third World * * * * * * * * * * * the apparent affinity of the tubercle bacillus for lymphoid tissue following the orientation of lymphoid follicles (i.e., longitudinal in the terminal ileum and transverse in the colon) * * Hematogenous spread from primary lung focus Ingestion of bacilli in sputum from active pulmonary focus. Direct spread from adjacent organs. Via lymph channels from infected LN * * * * * * * * * * * * * * * (1) Drugs for treatment First-line drugs: isoniazid (INH), rifampin, ethambutal, and streptomycin Second-line drugs: pyrazinamide, ethionamide, kanamycin, et al Drugs used to treat TB disease. From left to right isoniazid, rifampin, pyrazinamide, and ethambutol. Streptomycin (not shown) is given by injection Drug combination 2-drug combination of INH (3