微生物学通报近缘细菌细胞间的相互识别与相互作用.PDF

微生物学通报 Feb. 20, 2019, 46(2): 332−338 Microbiology China DOI: 10.13344/j.microbiol.china.180880 tongbao@ /wswxtbcn 专论与综述 近缘细菌细胞间的相互识别与相互作用 龚亚 李越中* 山东大学微生物技术国家重点实验室 微生物技术研究院 山东 青岛 266237 摘 要：亲缘识别是细菌细胞间竞争与合作的前提和基础。细菌通过亲缘识别分辨自我细胞和非自我 细胞；非同类的细菌细胞相互分离或被排除，而亲缘种群内的细菌细胞进行群体运动、生物膜和子实 体形成等社会性合作行为。细菌的自我识别机制可能有助于不同亲缘类群在混杂的自然系统中的共 存。近些年来，细菌亲缘识别及相互作用的机制研究工作成为热点，本文总结了近缘细菌细胞间相互 识别和作用机制的研究进展。 关键词：细菌，亲缘识别，菌落融合不兼容 Kin discrimination and interactions between bacterial siblings * GONG Ya LI Yue-Zhong State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China Abstract: Kin discrimination provides a means for bacterial individuals to identify self from non-self, and is thus the basis and prerequisite for the competition and cooperation among bacterial cells. By kin discrimination, competitive non-self-neighbors are separated from each other or are eliminated from self-populations, whereas the kin groups perform some exclusive social behaviors, such as social movement, biofilm formation and fruiting-body morphogenesis. Kin discrimination is thus suggested to aid the co-survival of different kin groups in nature. Recently, kin discrimination is becoming a hot spot in bacteriological studies. This review summarizes recent progresses in the mechanisms for bacterial kin discrimination and interactions. Keywords: Bacteria, Kin discrimination, Colony-merger incompatibility 细菌种类繁多，性质差异显著，是地球生物圈 是我们深入认识和利用细菌的重要基础。近二十年 中无处不在的生命体。细菌不但与环境中其他生物 来，组学与大数据等技术发展和创新，为攻克细菌 相互作用和相互依存，同时细菌种间和种内菌株之 群体复杂性研究提供了机遇和可能，并获得了长 间也相互协作，相互竞争，形成复杂的社会性群体