类风湿性关节炎痰瘀证与炎症因子相关性研究-中西医结合临床专业论文.docx

文献综述 文献综述 25 作者简历 。32 III 万方数据 中文摘要目的：本研究通过探讨类风湿性关节炎痰瘀证候与炎症因子的关系，以期为类风湿 中文摘要 目的：本研究通过探讨类风湿性关节炎痰瘀证候与炎症因子的关系，以期为类风湿 性关节炎的中医治疗提供较为客观的理论依据，充分挖掘中医在RA防治中的优势。 方法：采集符合纳入标准的类风湿性关节炎患者85例，分为痰瘀组43例，非痰瘀 组42例，收集患者临床资料，测定RF、CRP、ESR、Anti—CCP、IL一1、IL一6、TNF—Q等 炎症因子水平及X线分期、活动率和痰瘀积分，观察两组之间炎症因子水平、活动率、 X线表现，以及痰瘀积分与炎症因子之间是否存在相关性。 结果：痰瘀组与非痰瘀组组间性别、年龄、病程无差异。痰瘀组炎症指标RF、ESR、 CRP、Anti—CCP、IL一1、IL一6、TNF—Q水平显著高于非痰瘀组，活动率亦高于非痰瘀组， 痰瘀积分与炎症因子显著正相关，X线分期无显著性差异。 结论：类风湿性关节炎痰瘀痹阻型较非痰瘀痹阻型炎症因子水平升高，治疗上应注 重涤痰、化瘀。 关键词：类风湿性关节炎，痹证、痰瘀证，炎症因子 IV 万方数据 万方数据 万方数据 Abstractobiectives： Abstract obiectives： The akn of this study was to explore the relationship between the phieglnand blood stasis syndrome of rheumatoid arthritis and inflammatory factors，in order to provide a more objective basis for the theory oftraditional Chinese medicine treatment ofrheumatoid arthritis， and fully exploit the advantages of traditional Chinese medicine in the prevention and treatment of RA． Methods： 85 patients、析m clinically diagnosis RA from Traditional Chinese medicine hospital were recruited for this study，including 43 phlegm and blood stasis syndrome patients and 42 non·phlegm and blood stasis syndrome patients．And then collect the clinical data,the concentration of RF、CRP、ESR、Anti—CCP、IL-1、IL一6、TNF-0【were measured．the grade of X-ray Was also checked．We observed the level of these inflammatory markers、activity rate、X—ray stages between two groups，analyzed if there is a relationship correlation between phlegm and blood stasis score and inflammatory markers level． Results： There arc not difference between two groups，including age，sex and course．The phlegm and blood type’S inflammatory markers RF，ESR，CRP，IL一1，IL-6，TNF-a levels were significantly higher than non-phlegm and blood type，activity rate is higher than non—phlegm and blood type，but no significant differences in grade X—ray． Conclusion： The Phlegm group of rheumatoid arthritis has the elevated levels of inflammatory cytokines，and the treament should focus on anti．inflammation