磷光金属铱聚合物纳米粒子的合成及其在光学成像、核磁成像和光动力学治疗上的应用-无机化学专业论文.docx

Abst Abstract Shanghai Normal University Master of Science 万方数据 万方数据 (PVP).We can draw a conclusion from the experiments of SEM,TEM and stability detection in different solutions that nanoparticles were uniform, stability. The MRI experiments in solution and HeLa cells all present great T1-positive contrast effect. We have also investigated the bioimaging effect of Ir-Gd coordination polymer nanoparticles through laser scanning confocal microscopy in detail. The generation of singlet oxygen were detected in solution and trypan blue staining and a standard MTT assay were used to evaluate the efficacy of nanoparticles to eliminate cancer cells. All those results suggest that Ir-Gd nanoparticles have great prospect for photodynamic therapy. Keywords: Ir(III) complex; polymer nanoparticles; photodynamic therapy; optical imaging; MR imaging IV 上海 上海师范大学硕士学位论文 目录 目录 中文摘要.............................................................................................................................. I Abstract ............................................................................................................................. III 第一章 绪论....................................................................................................................... 1 1.1 配位聚合物纳米粒子的研究进展.............................................................................. 1 1.1.1 配位聚合物纳米粒子的合成........................................................................................... 1 1.1.2 配位聚合物纳米粒子的应用........................................................................................... 4 1.2 光动力学治疗..............................................................................................................11 1.2.1 光动力学治疗原理............................................................................................................ 12 1.2.2 光敏剂................................................................................................................................... 12 1.2.3 聚合