Drugsaffectingbloodandbloodformingorgans（作用于血液培训课件.pptVIP

Mechanism of Coumarins 2. Clinical uses Anti-coagulation in vivo(such as deep vein thrombosis, pulmonary emboli, and cardiac infarction, etc). 3. Adverse effects (1)Bleeding(9%～10%) Can affect all organs in body. Vitamin K1 may antagonist this reaction. can treat with fresh blood or plasma and prothrombin complex(凝血酶原复合物). (2)Necrosis of skin and parenchyma(皮肤和软组织坏死). (3)Liver injury(warfarin). Anticoagulant drugs 4. Drug interactions (1)Plasma protein binding replacement (2)Hepatic metabolism: enzyme inhibition enzyme induction Part 2. Antiplatelet drugs(抗血小板药) Thro