喹赛多及其主要代谢物在土壤中迁移转化研究-基础兽医学专业论文.docxVIP

华中农业大学2006届顾十学位论文药物的含量，并计算其降解半衰期。结果表明，喹赛多及其两种代谢物在土壤中降 华中农业大学2006届顾十学位论文 药物的含量，并计算其降解半衰期。结果表明，喹赛多及其两种代谢物在土壤中降 解较快。它们在土壤中的降解速度依次为脱二氧喹赛多喹赛多喹喔啉．2．羧酸， 降解半衰期分别为22．9～159．5h、28．1～192．2h和35．4～245．2h。并且，通过试验 发现，土壤中的微生物是影响三种药物降解的最主要因素。 本课题通过吸附、解吸和降解试验分析了喹赛多及其体内主要代谢物脱二氧喹 赛多和喹喔啉-2．羧酸在土壤中的迁移和转化能力，结果表明，喹赛多和喹喔啉．2． 羧酸在土壤中流动性很强，与土壤颗粒结合能力较弱，在土壤中降解也较快；脱二 氧喹赛多与土壤结合较牢固，但是其在土壤中降解半衰期很短，对土壤的危害作用 很低。本实验的完成填补了喹赛多及其代谢物土壤命运评估的空白，为指导实际生 产提供了一定的理论依据和保障。 。 关键词：喹赛多，脱二氧喹赛多，喹喔啉．2．羧酸，土壤，吸附，解吸，降解半 衰期 哇赛多及其主要代谢物在土壤中迁移转化研究The 哇赛多及其主要代谢物在土壤中迁移转化研究 The Mobility and Transformation of Cyadox and Its Main Metabolites in Soil Candidste：Zhang Zhimei Supervisor：Prof．Yuan Zonghui (Nationai Reference Laboratory ofVe蛐DrugResidues／MOA Key Laboratory of Food Safety Evaluation,Wuhan 430070．P．R China) Abstract Quinoxalines arc broad—spectrum antibiotics witIl growth-promoting activity,and have been extensively used in food animals since 1970s．Carbadox and olaquindox are the early members which have been strictly limited or banned to be used in food animals because of their toxicity to human and animals．Cyadox(CYⅪis a new candidate of quinoxalines．Some studies show that cyadox Can promote the growth and improve the feed conversion in broilers，swine，sheep and fish、】IritlI lower toxicity and higher safety． So cyadox will be all excellent replacer of the old quinoxalines．But there have not been any report concerning the toxicity of cyadox to the environment and the fate in the environmem．In this鼬甜y，the methods have been developed for the HPLC detection of cyadox and its main metabolites(desoxycyadox(DEO)and quinoxaline-2·carboxylic acid(QCA))in sandy loam and clay loam,and then reviewed the sorption and biodegradation ability of the three drugs in the soil．This study will provide some guidance for the dealing with the excreta ofthe hoggery and the bennery． The adsorption and desorption experiments a∞very important to evaluate the binding ability of the compo聃ds to the soil and this experiment assessed the adsorption abil